Recent advances in the synthetic and medicinal perspective of quinolones: A review
In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …
considering its clinical significance. Quinolones possess wide range of pharmacological …
Current scenario of quinolone hybrids with potential antibacterial activity against ESKAPE pathogens
J Gao, H Hou, F Gao - European Journal of Medicinal Chemistry, 2023 - Elsevier
Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …
14-and 15-membered lactone macrolides and their analogues and hybrids: Structure, molecular mechanism of action and biological activity
A Janas, P Przybylski - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …
[HTML][HTML] Actinomycete-derived polyketides as a source of antibiotics and lead structures for the development of new antimicrobial drugs
HL Robertsen, EM Musiol-Kroll - Antibiotics, 2019 - mdpi.com
Actinomycetes are remarkable producers of compounds essential for human and veterinary
medicine as well as for agriculture. The genomes of those microorganisms possess several …
medicine as well as for agriculture. The genomes of those microorganisms possess several …
[HTML][HTML] Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic …
Emergence of antimicrobial resistance has become a great threat to human species as there
is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR …
is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR …
The search for novel treatment strategies for Streptococcus pneumoniae infections
F Cools, P Delputte, P Cos - FEMS Microbiology Reviews, 2021 - academic.oup.com
This review provides an overview of the most important novel treatment strategies against
Streptococcus pneumoniae infections published over the past 10 years. The pneumococcus …
Streptococcus pneumoniae infections published over the past 10 years. The pneumococcus …
Synthesis, characterization, and density functional theory studies of hydrazone–oxime ligand derived from 2, 4, 6‐trichlorophenyl hydrazine and its metal complexes …
Novel 13 mononuclear complexes derived from 3‐(2‐(2, 4, 6‐trichlorophenyl) hydrazono)
butan‐2‐one oxime with various molar ratio, geometry and different mode of interaction …
butan‐2‐one oxime with various molar ratio, geometry and different mode of interaction …
Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of …
BZ Fan, H Hiasa, W Lv, S Brody, ZY Yang… - European Journal of …, 2020 - Elsevier
In the search for novel hybrid molecules by fusing two biologically active scaffolds into one
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …
heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin …
Design, Synthesis and Structure-activity Relationships of Novel Non-ketolides: 9-Oxime Clarithromycin Featured with Seven-to Thirteen-atom-length Diamine Linkers …
CX Ma, WT Liu, XM Li, J Ding, SM Liu, F Xue… - European Journal of …, 2024 - Elsevier
We report here on the structure-activity relationships of hybrids combining 3-descladinosyl
clarithromycin with quinolones linked by extended diamine connectors. Several hybrids …
clarithromycin with quinolones linked by extended diamine connectors. Several hybrids …
Recent advancements in macrolide hybrids against Staphylococcus aureus
C Ji, X Xu - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Staphylococcus aureus (S. aureus), recognized as one of the deadliest pathogens
responsible for nosocomial and community acquired infections, is highly contagious and …
responsible for nosocomial and community acquired infections, is highly contagious and …