Evidence-based policy: The promise ofrealist synthesis'

R Pawson - Evaluation, 2002 - journals.sagepub.com
Evaluation research is tortured by time constraints. The policy cycle revolves more quickly
than the research cycle, with the result thatreal time'evaluations often have little influence on …

Nicotine dependence: studies with a laboratory model

DH Malin - Pharmacology Biochemistry and Behavior, 2001 - Elsevier
Simple, rapid preclinical models of nicotine physical dependence and abstinence syndrome
are needed to identify underlying neurobiological mechanisms and screen potential …

Management of cardiovascular disease in renal transplant recipients

AC Shirali, MJ Bia - Clinical Journal of the American Society of …, 2008 - journals.lww.com
Cardiovascular disease is a major cause of graft loss and the leading cause of death in
renal transplant recipients. Although there are robust data on the frequency of risk factors …

The role of nitric oxide in cigarette smoking and nicotine addiction

W Vleeming, B Rambali… - Nicotine & tobacco …, 2002 - academic.oup.com
The purpose of this study is to describe the interrelationship between nitric oxide (NO) and
nicotine in cigarette smoking addiction, in view of the underlying hypothesis that NO …

Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance

EX Albuquerque, EFR Pereira, A Mike… - Behavioural brain …, 2000 - Elsevier
The present report describes the participation of nicotinic receptors (nAChRs) in controlling
the excitability of local neuronal circuitries in the rat hippocampus and in the human cerebral …

Investigations using immunization to attenuate the psychoactive effects of nicotine

MRA Carrera, JA Ashley, TZ Hoffman, S Isomura… - Bioorganic & medicinal …, 2004 - Elsevier
Despite the enormous health risks, people continue to smoke and use tobacco primarily as a
result of nicotine addiction. As part of our immunopharmacotherapy research, the effects of …

Stopping smoking: a prospective, randomized, double-blind study comparing nortriptyline to placebo

CL da Costa, RN Younes, MTC Lourenćo - Chest, 2002 - Elsevier
Objective The administration of antidepressant drugs was shown to positively affect the rate
of smoking cessation. This study evaluates the efficacy of nortriptyline in an antismoking …

A critique of nicotine addiction

H Frenk, R Dar - 2000 - books.google.com
Nicotine is almost universally believed to be the major factor that motivates smoking and
impedes cessation. Authorities such as the Surgeon General of the USA and the Royal …

Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome

DH Malin, JR Lake, A Lin, M Saldaña, L Balch… - Pharmacology …, 2001 - Elsevier
Passive immunization against nicotine interferes with its locomotor and pressor effects. The
current study determined whether immunization could prevent another nicotine action: the …

Evaluation of Rhodiola rosea L. extract on affective and physical signs of nicotine withdrawal in mice

L Mattioli, M Perfumi - Journal of Psychopharmacology, 2011 - journals.sagepub.com
The aim of the present study was to investigate the effects of a Rhodiola rosea L. extract on
the prevention of the development of nicotine dependence and for the reduction of …