Abstract Large multifunctional peptidase 7 (LMP7/β5i/PSMB8) is a proteolytic subunit of the
immunoproteasome, which is predominantly expressed in normal and malignant …

The proteasome is a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells
that controls numerous cellular processes through regulated protein degradation …

Proteasome inhibitors have been actively tested as potential anticancer drugs and in the
treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in …

Cell-mediated immunity is driven by antigenic peptide presentation on major
histocompatibility complex (MHC) molecules. Specialized proteasome complexes called …

The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

The cepafungins are a class of highly potent and selective eukaryotic proteasome inhibitor
natural products with potential to treat refractory multiple myeloma and other cancers. The …

Multiple myeloma (MM), a cancer of plasma cells, is the second most common
hematological malignancy which is characterized by aberrant plasma cells infiltration in the …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

Raised oxidative stress and abnormal redox status are typical features of multiple myeloma
cells, and the identification of the intimate mechanisms that regulate the relationships …

The immunoproteasome, a specialized form of proteasome, is mainly expressed in
lymphocytes and monocytes of jawed vertebrates and responsible for the generation of …