We have mined public genomic datasets to identify genes coding for components of the
ubiquitin proteasome system (UPS) that may qualify as potential diagnostic and therapeutic …

In serum proteomics using mass spectrometry, the number of detectable proteins is reduced
due to high-abundance proteins, such as albumin. However, recently developed data …

Simple Summary Tunneling nanotubes (TNTs) are cytoplasmic channels which regulate the
contacts between cells and allow the transfer of several elements, including ions …

Multiple myeloma (MM) is a hematological disease that is still not curable. The bone marrow
milieu, with cellular and non-cellular elements, participate in the creation of a pro-tumoral …

Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease that commonly
affects the kidneys. It is characterized by persistent autoantibody production that targets a …

Conventional chemotherapy has partial therapeutic effects against hematological
malignancies and is correlated with serious side effects and great risk of relapse. Recently …

Proteasome Inhibitors (PI) have now become the cornerstone of treatment of multiple
myeloma (MM). Carfilzomib has been demonstrated to cause more frequent cardiovascular …

Multiple myeloma (MM), a malignancy of plasma cells, is the second most prevalent blood
cancer (10%). A PubMed search has been conducted for English research papers and …

Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and
damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti …

The multiple myeloma (MM) therapeutic landscape has evolved significantly with the
approval of numerous novel agents, including next generation proteasome inhibitors (PIs) …