The human immune system has structures called checkpoints controlling the intensity and
the duration of immune responses. In the last years, studies and research have been …

The prognosis for newly diagnosed subjects with multiple myeloma (MM) has significantly
progressed in recent years. However, most MM patients relapse and after several salvage …

Multiple myeloma is a malignant disease, caused by an uncontrolled clonal proliferation of a
specific group of white blood cells, the plasma cells. Clinical manifestations include bone …

Inhibitors of the proteasome have been extensively studied for their applications in the
treatment of human diseases such as hematologic malignancies, autoimmune disorders …

The immunoproteasome contains three catalytic subunits (β1i, β2i and β5i) that are
important modulators of immune cell homeostasis. A previous study showed a correlation …

PA28α/β activated immunoproteasome frequently participates in MHC class I antigen
processing, however, whether it is involved in breast tumor progression remains largely …

The immunoproteasome, a specialized variant of the constitutive one, is predominantly
expressed in lymphocytes and monocytes of jawed vertebrates and is considered to be …

Simple Summary YES-associated protein (YAP) is a co-transcriptional activator that binds to
transcriptional factors to increase the rate of transcription of a set of genes, and it can …

The use of viruses for tumour treatment has been imagined more than one hundred years
ago, when it was reported that viral diseases were occasionally leading to a decrease in …

The proteasome regulates intracellular processes, maintains biological homeostasis, and
has shown great significance in the study of various diseases, such as neurodegenerative …