Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has
several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction …

Abstract A series of N, C-capped di-and tripeptides were designed as selective
immunoproteasome inhibitors based on the known inhibitor 4-CA. Forty-eight new …

A series of novel non-covalent peptidomimetic proteasome inhibitors possessing bulky
group at the C-terminus and N-alkylation at the N-terminus were designed with the aim to …

Background/Aim: Although numerous cytokines influence proliferation and progression of
multiple myeloma (MM), a relevant action in the onset of the disease also seems to be …

IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and renal failure. The
exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel …

The degradation of most intracellular proteins is a dynamic and tightly regulated process
performed by proteasomes. To date, different forms of proteasomes have been identified …

Sažetak The constitutive proteasome and the immunoproteasome represent validated
targets for pharmacological intervention in the context of various diseases, such as cancer …

The selective inhibition of immunoproteasome is a valuable strategy to treat autoimmune,
inflammatory diseases, and hematologic malignancies. Recently, a new series of amide …

The immunoproteasome is a multicatalytic protease that is predominantly expressed in cells
of hematopoietic origin. Its elevated expression has been associated with autoimmune …

Immunoproteasome inhibition is a promising strategy for the treatment of hematological
malignancies, autoimmune diseases, and inflammatory diseases. The design of non …