As proteasome inhibitors, a series of novel macrocyclic dipeptide N-benzyl amides were
designed, synthesized and evaluated. Most of them exhibited potent proteasome inhibition …

Proteasomes are established therapeutic targets for hematological cancers and promising
targets for autoimmune diseases. In the past, we have designed and synthesized …

Drug repositioning is a strategy to identify new uses for approved or investigational drugs
that are used off-label outside the scope of the original medical indication. In this review, we …

El mieloma múltiple (MM) es una neoplasia caracterizada por la proliferación clonal de
células plasmáticas patológicas, principalmente en la médula ósea. Constituye el 10% de …

Several neurotransmitters and neuropeptides were reported to join in or cooperate with
different cells of the immune system, bone marrow, and peripheral cells. Numerous data …

A series of epoxyketone analogues with varying N-caps and P3-configurations were
designed, synthesized and evaluated. We found that D-Ala in P3 was crucial for β5i …

El mieloma múltiple (MM) es una neoplasia caracterizada por la proliferación clonal de
células plasmáticas patológicas, principalmente en la médula ósea. Constituye el 10% de …

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease. Although the
lack of dystrophin protein is the primary defect responsible for the development of DMD …

Inhibition of the immunoproteasome (iCP) offers new opportunities in the treatment of
cancer, autoimmune disorders and neurodegenerative diseases. Inspired by the success of …

The identification of effective and selective immunoproteasome inhibitors could greatly
promote smart treatment of many autoimmune, inflammatory and tumor diseases. This paper …