Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

Why do we get cancer mostly when we are old? According to current paradigms, the answer
is simple: mutations accumulate in our tissues throughout life, and some of these mutations …

Although it is widely accepted that most cancers exhibit some degree of intratumour
heterogeneity, we are far from understanding the dynamics that operate among …

Interactions between tumour cells and the surrounding microenvironment contribute to
tumour progression, metastasis and recurrence,–. Although mosaic analyses in Drosophila …

The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …

Cell competition involves a conserved fitness-sensing process during which fitter cells
eliminate neighbouring less-fit but viable cells. Cell competition has been proposed as a …

Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell
competition, cells with a heterozygous mutation in ribosome genes, such as RpS3+/− cells …

Astrocytes are critically important for neuronal circuit assembly and function. Mammalian
protoplasmic astrocytes develop a dense ramified meshwork of cellular processes to form …

Chimaeras are both monsters of the ancient imagination and a long-established research
tool. Recent advances, particularly those dealing with the identification and generation of …