Model‐informed drug development for anti‐infectives: state of the art and future

CR Rayner, PF Smith, D Andes… - Clinical …, 2021 - Wiley Online Library
Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …

Advances in the design of combination therapies for the treatment of tuberculosis

J Larkins-Ford, BB Aldridge - Expert opinion on drug discovery, 2023 - Taylor & Francis
Introduction Tuberculosis requires lengthy multi-drug therapy. Mycobacterium tuberculosis
occupies different tissue compartments during infection, making drug access and …

[HTML][HTML] A fractional dynamics of tuberculosis (TB) model in the frame of generalized Atangana–Baleanu derivative

W Shatanawi, MS Abdo, MA Abdulwasaa, K Shah… - Results in Physics, 2021 - Elsevier
In the present paper, we formulate novel fractional tuberculosis (TB) model with a
generalized Atangana–Baleanu (GAB) fractional derivative. The parameters in this model …

Emerging therapeutics, technologies, and drug development strategies to address patient nonadherence and improve tuberculosis treatment

M Garcia-Cremades, BP Solans… - Annual Review of …, 2022 - annualreviews.org
Imperfect medication adherence remains the biggest predictor of treatment failure for
patients with tuberculosis. Missed doses during treatment lead to relapse, tuberculosis …

[HTML][HTML] Pharmacometrics in tuberculosis: progress and opportunities

JJ Wilkins, EM Svensson, JP Ernest, RM Savic… - International Journal of …, 2022 - Elsevier
Tuberculosis (TB) remains one of the leading causes of death by a communicable agent,
infecting up to one-quarter of the world's population, predominantly in disadvantaged …

Optimal regulation of tumour-associated neutrophils in cancer progression

AA de Los Reyes, Y Kim - Royal Society Open Science, 2022 - royalsocietypublishing.org
In a tumour microenvironment, tumour-associated neutrophils could display two opposing
differential phenotypes: anti-tumour (N1) and pro-tumour (N2) effector cells. Converting N2 …

Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches

K Mehta, HP Spaink, THM Ottenhoff… - Trends in …, 2022 - cell.com
Host-directed therapies (HDTs) that modulate host–pathogen interactions offer an innovative
strategy to combat Mycobacterium tuberculosis (Mtb) infections. When combined with …

[HTML][HTML] Fractal fractional model for tuberculosis: existence and numerical solutions

A Khan, K Shah, T Abdeljawad, I Amacha - Scientific Reports, 2024 - nature.com
This paper deals with the mathematical analysis of Tuberculosis by using fractal fractional
operator. Mycobacterium TB is the bacteria that causes tuberculosis. This airborne illness …

Integration of transcriptomics and system pharmacology to reveal the therapeutic mechanism underlying Qingfei Xiaoyan Wan to treat allergic asthma

JY Hou, JR Wu, D Xu, YB Chen, DD Shang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Asthma is a chronic inflammatory disease, characterized
by airway inflammation, hyperresponsiveness, and bronchial smooth muscle contraction …

Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease

V Dartois, T Dick - Nature Reviews Drug Discovery, 2024 - nature.com
Tuberculosis (TB) drug discovery and development has undergone nothing short of a
revolution over the past 20 years. Successful public–private partnerships and sustained …