Tumor-associated macrophages: An effective player of the tumor microenvironment
U Basak, T Sarkar, S Mukherjee… - Frontiers in …, 2023 - frontiersin.org
Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …
[HTML][HTML] Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma
I Truxova, D Cibula, R Spisek… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …
[HTML][HTML] From degenerative disease to malignant tumors: insight to the function of ApoE
G Miao, D Zhuo, X Han, W Yao, C Liu, H Liu… - Biomedicine & …, 2023 - Elsevier
Apolipoprotein E (ApoE) is a multifunctional protein involved in lipid transport and
lipoprotein metabolism, mediating lipid distribution/redistribution in tissues and cells. It can …
lipoprotein metabolism, mediating lipid distribution/redistribution in tissues and cells. It can …
Immune modulatory properties of collagen in cancer
AMA Rømer, ML Thorseth, DH Madsen - Frontiers in immunology, 2021 - frontiersin.org
During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …
High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints
AM Raghubar, NA Matigian, J Crawford… - npj Precision …, 2023 - nature.com
Perioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell
renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient …
renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient …
Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition
Over the past decade, immune checkpoint inhibitor (ICI) therapy has been established as
the standard of care for many types of cancer, but the strategies employed have continued to …
the standard of care for many types of cancer, but the strategies employed have continued to …
[HTML][HTML] β-Catenin signaling in alveolar macrophages enhances lung metastasis through a TNF-dependent mechanism
ED Kramer, SL Tzetzo, SH Colligan, ML Hensen… - JCI insight, 2023 - ncbi.nlm.nih.gov
The main cause of malignancy-related mortality is metastasis. Although metastatic
progression is driven by diverse tumor-intrinsic mechanisms, there is a growing appreciation …
progression is driven by diverse tumor-intrinsic mechanisms, there is a growing appreciation …
Integrative insights and clinical applications of single-cell sequencing in cancer immunotherapy
Z Liu, H Li, Q Dang, S Weng, M Duo, J Lv… - Cellular and Molecular …, 2022 - Springer
Recently, immunotherapy has gained increasing popularity in oncology. Several
immunotherapies obtained remarkable clinical effects, but the efficacy varied, and only …
immunotherapies obtained remarkable clinical effects, but the efficacy varied, and only …
Human tumor targeted cytotoxic mast cells for cancer immunotherapy
The diversity of autologous cells being used and investigated for cancer therapy continues
to increase. Mast cells (MCs) are tissue cells that contain a unique set of anti-cancer …
to increase. Mast cells (MCs) are tissue cells that contain a unique set of anti-cancer …
Noncoding RNA-mediated macrophage and cancer cell crosstalk in hepatocellular carcinoma
Z Zhou, Z Wang, J Gao, Z Lin, Y Wang, P Shan… - Molecular Therapy …, 2022 - cell.com
The tumor microenvironment (TME) is a well-recognized system that plays an essential role
in tumor initiation, development, and progression. Intense intercellular communication …
in tumor initiation, development, and progression. Intense intercellular communication …