Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …

Apolipoprotein E (ApoE) is a multifunctional protein involved in lipid transport and
lipoprotein metabolism, mediating lipid distribution/redistribution in tissues and cells. It can …

During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …

Perioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell
renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient …

Over the past decade, immune checkpoint inhibitor (ICI) therapy has been established as
the standard of care for many types of cancer, but the strategies employed have continued to …

The main cause of malignancy-related mortality is metastasis. Although metastatic
progression is driven by diverse tumor-intrinsic mechanisms, there is a growing appreciation …

Recently, immunotherapy has gained increasing popularity in oncology. Several
immunotherapies obtained remarkable clinical effects, but the efficacy varied, and only …

The diversity of autologous cells being used and investigated for cancer therapy continues
to increase. Mast cells (MCs) are tissue cells that contain a unique set of anti-cancer …

The tumor microenvironment (TME) is a well-recognized system that plays an essential role
in tumor initiation, development, and progression. Intense intercellular communication …