Cyclooxygenase‐2 in cancer: a review

N Hashemi Goradel, M Najafi, E Salehi… - Journal of cellular …, 2019 - Wiley Online Library
Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

[HTML][HTML] Biological activity of sacha inchi (Plukenetia volubilis Linneo) and potential uses in human health: A review

DM Cárdenas, LJ Gómez Rave, JA Soto - Food Technology and …, 2021 - hrcak.srce.hr
Sažetak Sacha inchi (Plukenetia volubilis Linneo) is an ancestral plant originating in the
Amazon jungle that has been adopted as a food source due to its high nutritional value …

[HTML][HTML] Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

Y Peng, Y Wang, N Tang, D Sun, Y Lan, Z Yu… - Journal of Experimental …, 2018 - Springer
Abstract Background Andrographolide (Andro), a diterpenoid lactone, has been used for
treatment of various cancers with less adverse effects. However, the underlying mechanisms …

[HTML][HTML] MiR-7-5p is involved in ferroptosis signaling and radioresistance thru the generation of ROS in radioresistant HeLa and SAS cell lines

K Tomita, T Nagasawa, Y Kuwahara, S Torii… - International Journal of …, 2021 - mdpi.com
In cancer therapy, radioresistance or chemoresistance cells are major problems. We
established clinically relevant radioresistant (CRR) cells that can survive over 30 days after …

The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches

N Zafari, F Khosravi, Z Rezaee… - Journal of Clinical …, 2022 - Wiley Online Library
Background Colorectal cancer (CRC) with a high prevalence is recognized as the fourth
most common cause of cancer‐related death globally. Over the past decade, there has been …

The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis

Z Yu, Y Peng, J Gao, M Zhou, L Shi, F Zhao… - Science …, 2023 - science.org
P23, historically known as a heat shock protein 90 (HSP90) co-chaperone, exerts some of its
critical functions in an HSP90-independent manner, particularly when it translocates into the …

[HTML][HTML] CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway

X Wang, W Sheng, T Xu, J Xu, R Gao… - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) have critical regulatory roles in tumor biology. However, their
contributions in hepatocellular carcinoma (HCC) still remain enigmatic. The present study …

[HTML][HTML] Angiogenesis-related functions of Wnt signaling in colorectal carcinogenesis

A Kasprzak - Cancers, 2020 - mdpi.com
Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

Targeting the redox imbalance in mitochondria: A novel mode for cancer therapy

S Mani, G Swargiary, SJ Ralph - Mitochondrion, 2022 - Elsevier
Abstract Changes in reactive oxygen species (ROS) levels affect many aspects of cell
behavior. During carcinogenesis, moderate ROS production modifies gene expression to …

[HTML][HTML] In vivo and in vitro Approach to Anti-arthritic and Anti-inflammatory Effect of Crocetin by Alteration of Nuclear Factor-E2-Related Factor 2/hem Oxygenase …

Y Li, R Kakkar, J Wang - Frontiers in pharmacology, 2018 - frontiersin.org
Crocetin (apo carotenoid dicarboxylic acid) is a common constituent of saffron. Its
importance is well documented in Chinese medicine. Some studies have reported the …