Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …

Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive
disorder characterized by a near complete lack of adipose tissue from birth and, later in life …

Drusen are discussed frequently in the context of their association with age-related macular
degeneration (AMD). Some types may, however, be regarded as a normal consequence of …

OBJECTIVE Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and
outcomes. In previous work, we investigated the genetic basis of this heterogeneity by …

Adipose tissue not only stores energy, but also controls metabolism through secretion of
hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues …

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the
immune system by activating inflammatory caspases and cytokines such as IL-1β. The …

Abstract Purpose of Review Genetic or acquired lipodystrophies are characterized by
selective loss of body fat along with predisposition towards metabolic complications of …

Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and
how these characteristics may be exploited as therapeutic targets. Much attention has …

Lipodystrophy constitutes a spectrum of diseases characterized by a generalized or partial
absence of adipose tissue. Underscoring the role of healthy fat in maintenance of metabolic …

Metabolic diseases such as type 2 diabetes are a major public health issue worldwide.
These diseases are often linked to a dysfunctional adipose tissue. Fat is a large …