Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Intake of processed foods has increased markedly over the past decades, coinciding with
increased microvascular diseases such as chronic kidney disease (CKD) and diabetes …

Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species,
taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in
the United States and many other countries. DKD occurs through a variety of pathogenic …

Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …

Podocytes are a crucial cellular component in maintaining the glomerular filtration barrier,
and their injury is the major determinant in the development of albuminuria and diabetic …

Increasing evidence supports a role of proximal tubular (PT) injury in the progression of
diabetic kidney disease (DKD), in patients with or without proteinuria. Research on the …

In healthy kidneys, interstitial fibroblasts are responsible for the maintenance of renal
architecture. Progressive interstitial fibrosis is thought to be a common pathway for chronic …

Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …