Diversity within the fungal kingdom is evident from the wide range of morphologies fungi
display as well as the various ecological roles and industrial purposes they serve …

The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal
pathogens with different phenotypic and genotypic diversity that cause disease in …

Cryptococcosis is an invasive fungal infection of humans and other animals, typically caused
by the species Cryptococcus neoformans in patients with impaired immunity. However, there …

Infectious microorganisms often play a role in modulating the immune responses of their
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

Microorganisms are significantly affected when the ambient pH of their environment
changes. They must therefore be able to sense and respond to these changes in order to …

Brain infection by the fungus Cryptococcus neoformans results in inflammation of the
meninges and brain parenchyma, a condition known as meningoencephalitis. One million …

The pathogenic yeast Cryptococcus neoformans produces polyploid titan cells in response
to the host lung environment that are critical for host adaptation and subsequent disease …

We have studied infection of Cryptococcus neoformans in the non-vertebrate host Galleria
mellonella with particular interest in the morphological response of the yeast. Inoculation of …

The titan cell is a recently described morphological form of the pathogenic fungus
Cryptococcus neoformans. Occurring during the earliest stages of lung infection, titan cells …