The efficacy of zuranolone in postpartum depression and major depressive disorder: a review & number needed to treat (NNT) analysis

DS Cha, N Kleine, KM Teopiz… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Major depressive disorder (MDD) is a common and debilitating mental illness.
Postpartum depression (PPD) impacts women globally and is one of the most common …

[HTML][HTML] Exploring novel therapeutic approaches for depressive disorders: the role of allopregnanolone agonists

NA Bhatti, A Jobilal, K Asif, MJ Villegas, P Pandey… - Cureus, 2023 - ncbi.nlm.nih.gov
Depressive disorders are caused due to the impaired functioning of important brain
networks. Recent studies have also shown that it is caused by a significant reduction in the …

[HTML][HTML] Neuropsychiatric adverse effects from CFTR modulators deserve a serious research effort

MB VanElzakker, EM Tillman, LM Yonker… - Current Opinion in …, 2023 - journals.lww.com
Although ETI is well tolerated by most PwCF, some experience debilitating neuropsychiatric
AEs. In some cases, these AEs may be driven by modulation of CFTR and chloride transport …

Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome

K Marinkovic, DR White, A Alderson Myers, KS Parker… - Brain Sciences, 2023 - mdpi.com
After recovering from the acute COVID-19 illness, a substantial proportion of people
continue experiencing post-acute sequelae of COVID-19 (PASC), also termed “long COVID” …

[HTML][HTML] Sclareol antagonizes the sedative effect of diazepam in thiopental sodium-induced sleeping animals: In vivo and in silico studies

SMH Hassan, HAS El-Nashar, MA Rahman… - Biomedicine & …, 2024 - Elsevier
Background Sclareol (SCL), a labdane diterpene compound found in Salvia sclarea L.,
exhibited therapeutic effects. This study investigated the potential interaction between SCL …

Mapping the depressed brain under stress using multimodal neuroimaging

TJ Akiki, CG Abdallah - American Journal of Psychiatry, 2024 - psychiatryonline.org
Establishing the biological signatures of human emotions, thoughts, and behavior has long
been the holy grail of neuroscience research. Advancements in brain imaging and …

Temporal dissociation between local and global functional adaptations of the maternal brain to childbirth: a longitudinal assessment

LD Lotter, S Nehls, E Losse, J Dukart… - …, 2024 - nature.com
The maternal brain undergoes significant reorganization during birth and the postpartum
period. However, the temporal dynamics of these changes remain unclear. Using resting …

Astrocytic GABAergic Regulation in Alcohol Use and Major Depressive Disorders

DN Ali, HM Ali, MR Lopez, S Kang, DS Choi - Cells, 2024 - mdpi.com
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central
nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and …

The efficacy and safety of Zuranolone for treatment of depression: A systematic review and meta-analysis

AM Fayoud, HA Orebi, IA Elshnoudy, MAT Elsebaie… - …, 2024 - Springer
Methods Five databases were searched until September 2023 for relevant randomized
clinical trials evaluating the efficacy and safety of zuranolone. The potential risk of bias in the …

Different dosage regimens of zuranolone in the treatment of major depressive disorder: A meta-analysis of randomized controlled trials

J Lian, Z Lin, X Li, G Chen, D Wu - Journal of Affective Disorders, 2024 - Elsevier
Objective To investigate the efficacy and safety of different dosage regimens of zuranolone
in the treatment of patients with major depressive disorder (MDD). Methods PubMed …