The efficacy of zuranolone in postpartum depression and major depressive disorder: a review & number needed to treat (NNT) analysis
DS Cha, N Kleine, KM Teopiz… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Major depressive disorder (MDD) is a common and debilitating mental illness.
Postpartum depression (PPD) impacts women globally and is one of the most common …
Postpartum depression (PPD) impacts women globally and is one of the most common …
[HTML][HTML] Exploring novel therapeutic approaches for depressive disorders: the role of allopregnanolone agonists
NA Bhatti, A Jobilal, K Asif, MJ Villegas, P Pandey… - Cureus, 2023 - ncbi.nlm.nih.gov
Depressive disorders are caused due to the impaired functioning of important brain
networks. Recent studies have also shown that it is caused by a significant reduction in the …
networks. Recent studies have also shown that it is caused by a significant reduction in the …
[HTML][HTML] Neuropsychiatric adverse effects from CFTR modulators deserve a serious research effort
Although ETI is well tolerated by most PwCF, some experience debilitating neuropsychiatric
AEs. In some cases, these AEs may be driven by modulation of CFTR and chloride transport …
AEs. In some cases, these AEs may be driven by modulation of CFTR and chloride transport …
Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome
K Marinkovic, DR White, A Alderson Myers, KS Parker… - Brain Sciences, 2023 - mdpi.com
After recovering from the acute COVID-19 illness, a substantial proportion of people
continue experiencing post-acute sequelae of COVID-19 (PASC), also termed “long COVID” …
continue experiencing post-acute sequelae of COVID-19 (PASC), also termed “long COVID” …
[HTML][HTML] Sclareol antagonizes the sedative effect of diazepam in thiopental sodium-induced sleeping animals: In vivo and in silico studies
Background Sclareol (SCL), a labdane diterpene compound found in Salvia sclarea L.,
exhibited therapeutic effects. This study investigated the potential interaction between SCL …
exhibited therapeutic effects. This study investigated the potential interaction between SCL …
Mapping the depressed brain under stress using multimodal neuroimaging
TJ Akiki, CG Abdallah - American Journal of Psychiatry, 2024 - psychiatryonline.org
Establishing the biological signatures of human emotions, thoughts, and behavior has long
been the holy grail of neuroscience research. Advancements in brain imaging and …
been the holy grail of neuroscience research. Advancements in brain imaging and …
Temporal dissociation between local and global functional adaptations of the maternal brain to childbirth: a longitudinal assessment
The maternal brain undergoes significant reorganization during birth and the postpartum
period. However, the temporal dynamics of these changes remain unclear. Using resting …
period. However, the temporal dynamics of these changes remain unclear. Using resting …
Astrocytic GABAergic Regulation in Alcohol Use and Major Depressive Disorders
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central
nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and …
nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and …
The efficacy and safety of Zuranolone for treatment of depression: A systematic review and meta-analysis
AM Fayoud, HA Orebi, IA Elshnoudy, MAT Elsebaie… - …, 2024 - Springer
Methods Five databases were searched until September 2023 for relevant randomized
clinical trials evaluating the efficacy and safety of zuranolone. The potential risk of bias in the …
clinical trials evaluating the efficacy and safety of zuranolone. The potential risk of bias in the …
Different dosage regimens of zuranolone in the treatment of major depressive disorder: A meta-analysis of randomized controlled trials
J Lian, Z Lin, X Li, G Chen, D Wu - Journal of Affective Disorders, 2024 - Elsevier
Objective To investigate the efficacy and safety of different dosage regimens of zuranolone
in the treatment of patients with major depressive disorder (MDD). Methods PubMed …
in the treatment of patients with major depressive disorder (MDD). Methods PubMed …