Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing

CJY Tsai, JMS Loh, T Proft - Virulence, 2016 - Taylor & Francis
abstract Galleria mellonella (greater wax moth or honeycomb moth) has been introduced as
an alternative model to study microbial infections. G. mellonella larvae can be easily and …

Innate humoral immune defences in mammals and insects: The same, with differences?

G Sheehan, A Garvey, M Croke, K Kavanagh - Virulence, 2018 - Taylor & Francis
The insect immune response demonstrates many similarities to the innate immune response
of mammals and a wide range of insects is now employed to assess the virulence of …

From flies to men: ROS and the NADPH oxidase in phagocytes

ZM Moghadam, P Henneke, J Kolter - Frontiers in cell and …, 2021 - frontiersin.org
The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …

An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes

N Browne, M Heelan, K Kavanagh - Virulence, 2013 - Taylor & Francis
The insect immune response demonstrates a number of structural and functional similarities
to the innate immune system of mammals. As a result of these conserved features insects …

Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens

TC Pereira, PP De Barros, LRO Fugisaki, RD Rossoni… - Journal of Fungi, 2018 - mdpi.com
The use of invertebrates for in vivo studies in microbiology is well established in the scientific
community. Larvae of Galleria mellonella are a widely used model for studying …

Immune Response of Galleria mellonella against Human Fungal Pathogens

N Trevijano-Contador, O Zaragoza - Journal of Fungi, 2018 - mdpi.com
In many aspects, the immune response against pathogens in insects is similar to the innate
immunity in mammals. This has caused a strong interest in the scientific community for the …

The Use of Galleria mellonella Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest

K Kavanagh, G Sheehan - Journal of Fungi, 2018 - mdpi.com
The immune system of insects and the innate immune response of mammals share many
similarities and, as a result, insects may be used to assess the virulence of fungal pathogens …

Accumulation and trafficking of zinc oxide nanoparticles in an invertebrate model, Bombyx mori, with insights on their effects on immuno-competent cells

AH Mir, A Qamar, I Qadir, AH Naqvi, R Begum - Scientific reports, 2020 - nature.com
Abstract Zinc oxide nanoparticles (ZnO NPs) are used in many applications; however, their
interactions with cells, immune cells in particular, and potential health risk (s) are not fully …

[HTML][HTML] Invertebrate models of fungal infection

M Arvanitis, J Glavis-Bloom, E Mylonakis - Biochimica et Biophysica Acta …, 2013 - Elsevier
The morbidity, mortality and economic burden associated with fungal infections, together
with the emergence of fungal strains resistant to current antimicrobial agents, necessitate …

Aspergillus fumigatus Inhibits Pseudomonas aeruginosa in Co-culture: Implications of a Mutually Antagonistic Relationship on Virulence and Inflammation in the CF …

E Reece, S Doyle, P Greally, J Renwick… - Frontiers in …, 2018 - frontiersin.org
Many cystic fibrosis (CF) airway infections are considered to be polymicrobial and microbe–
microbe interactions may play an important role in disease pathology. Pseudomonas …