In this paper we argue that compulsive overeating has compelling similarities to
conventional drug addiction. Our case is based on their comparable clinical features, the …

Here we review the emerging neurobiological understanding of the role of the brain's reward
system in the regulation of body weight in health and in disease. Common obesity is …

Obesity is associated with physical inactivity, which exacerbates the health consequences of
weight gain. However, the mechanisms that mediate this association are unknown. We …

The nucleus accumbens (NAcc) mediates feeding reward; its activity reflects tastants'
hedonic value. NAcc dopamine guides immediate responses to reward, however, its …

Attention-deficit/hyperactivity disorder (ADHD) affects nearly 10% of children in the United
States, and the prevalence of this disorder has increased steadily over the past decades …

Polypeptides produced in the gastrointestinal tract, stomach, adipocytes, pancreas and brain
that influence food intake are referred to as 'feeding-related'peptides. Most peptides that …

High impulsivity, mediated through ventral striatal dopamine signalling, represents an
established risk factor for substance abuse, and may likewise confer vulnerability to …

Food reward, not hunger, is the main driving force behind eating in the modern obesogenic
environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily …

The obesity epidemic is a leading cause of health problems in the United States, increasing
the risk of cardiovascular, endocrine, and psychiatric diseases. Although many people lose …

An early study performed in Bart Hoebel's laboratory suggested that dopamine (DA)
signaling in the nucleus accumbens was involved in learned flavor preferences produced by …