Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
Polymeric Biomaterials for In Vitro Cancer Tissue Engineering and Drug Testing Applications
Biomimetic polymers and materials have been widely used in tissue engineering for
regeneration and replication of diverse types of both normal and diseased tissues. Cancer …
regeneration and replication of diverse types of both normal and diseased tissues. Cancer …
[HTML][HTML] Mimicking tumor hypoxia in non-small cell lung cancer employing three-dimensional in vitro models
I Ziółkowska-Suchanek - Cells, 2021 - mdpi.com
Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects
cancer progression, metastasis and metabolism. Oxygen induces both proteomic and …
cancer progression, metastasis and metabolism. Oxygen induces both proteomic and …
[HTML][HTML] Organ-tumor-on-a-chip for chemosensitivity assay: a critical review
With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death
worldwide. However, the emerging field of microfluidics can potentially shed light on this …
worldwide. However, the emerging field of microfluidics can potentially shed light on this …
Emerging trends in the methodology of environmental toxicology: 3D cell culture and its applications
H Wang, T Xu, D Yin - Science of The Total Environment, 2023 - Elsevier
Human diseases and health concerns caused by environmental pollutants are globally
emerging. Therefore, rapid and efficient evaluation of the effects of environmental pollutants …
emerging. Therefore, rapid and efficient evaluation of the effects of environmental pollutants …
Microfluidic nanodevices for drug sensing and screening applications
The outbreak of pandemics (eg, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2 in 2019), influenza A viruses (H1N1 in 2009), etc.), and worldwide spike in the aging …
CoV-2 in 2019), influenza A viruses (H1N1 in 2009), etc.), and worldwide spike in the aging …
[HTML][HTML] Microscopic imaging methods for organ-on-a-chip platforms
BC Buchanan, JY Yoon - Micromachines, 2022 - mdpi.com
Microscopic imaging is essential and the most popular method for in situ monitoring and
evaluating the outcome of various organ-on-a-chip (OOC) platforms, including the number …
evaluating the outcome of various organ-on-a-chip (OOC) platforms, including the number …
Micro-scaffold array chip for upgrading cell-based high-throughput drug testing to 3D using benchtop equipment
Cell-based high throughput drug screening accelerates the pace of drug discovery which is
routinely operated on planar high-density multi-well plates with sophisticated robotic liquid …
routinely operated on planar high-density multi-well plates with sophisticated robotic liquid …
Applicability of drug response metrics for cancer studies using biomaterials
EA Brooks, S Galarza, MF Gencoglu… - … of the Royal …, 2019 - royalsocietypublishing.org
Bioengineers have built models of the tumour microenvironment (TME) in which to study cell–
cell interactions, mechanisms of cancer growth and metastasis, and to test new therapies …
cell interactions, mechanisms of cancer growth and metastasis, and to test new therapies …
In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies
The complexity and heterogeneity of the three-dimensional (3D) tumor microenvironment
have brought challenges to tumor studies and cancer treatment. The complex functions and …
have brought challenges to tumor studies and cancer treatment. The complex functions and …