Metastatic disease is responsible for approximately 90% of cancer deaths. For successful
dissemination and metastasis, cancer cells must evade detection and destruction by the …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Interleukin-1β (IL-1β) is abundant in the tumor microenvironment, where this cytokine can
promote tumor growth, but also antitumor activities. We studied IL-1β during early tumor …

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non–small cell
lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes …

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …

Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Interleukin-1 is a cytokine with potent inflammatory and immune-amplifying effects, mainly
produced by macrophages during defensive reactions. In mammals, IL-1 is a superfamily of …

Tumor angiogenesis is one of the hallmarks of tumor progression and is essential for
invasiveness and metastasis. Myeloid inflammatory cells, such as immature myeloid …

Cancer immunotherapy has veered the paradigm of cancer treatment. Despite recent
advances in immunotherapy for improved antitumor efficacy, the complicated tumor …

IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating
immune cells in several cancer models. We hypothesized that IL-22 regulation would occur …