Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth
C Voigt, P May, A Gottschlich… - Proceedings of the …, 2017 - National Acad Sciences
IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating
immune cells in several cancer models. We hypothesized that IL-22 regulation would occur …
immune cells in several cancer models. We hypothesized that IL-22 regulation would occur …
Interleukins 1 and 6 as main mediators of inflammation and cancer
OS Dmitrieva, IP Shilovskiy, MR Khaitov… - Biochemistry …, 2016 - Springer
The idea of a potential link between cancer and inflammation was first proposed by R.
Virchow in the nineteenth century. However, clear evidence regarding a key role of …
Virchow in the nineteenth century. However, clear evidence regarding a key role of …
[HTML][HTML] Role of chitinase-like proteins in cancer
J Kzhyshkowska, S Yin, T Liu, V Riabov… - Biological …, 2016 - degruyter.com
Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …
Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression
R Takahashi, M Macchini, M Sunagawa, Z Jiang… - Gut, 2021 - gut.bmj.com
Objective Long-standing chronic pancreatitis is an established risk factor for pancreatic
ductal adenocarcinoma (PDAC). Interleukin-1β (IL-1β) has been associated in PDAC with …
ductal adenocarcinoma (PDAC). Interleukin-1β (IL-1β) has been associated in PDAC with …
[HTML][HTML] Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide
Traditional uses of herbal medicine have depended mostly on anecdotal evidence for much
of history. The increasing application of scientific rigor to the study some of these traditional …
of history. The increasing application of scientific rigor to the study some of these traditional …
A primer on cytokines
Cytokines are pleiotropic polypeptides that control the development of and responses
mediated by immune cells. Cytokine classification predominantly relies on [1] the target …
mediated by immune cells. Cytokine classification predominantly relies on [1] the target …
Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
Macroautophagy (hereafter autophagy) is a cellular “self-eating” process that is implicated in
many human cancers, where it can act to either promote or suppress tumorigenesis …
many human cancers, where it can act to either promote or suppress tumorigenesis …
The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities
The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …
inflammation and acquired immunity. Over the last decades, several progresses have been …
[HTML][HTML] IL-1α processing, signaling and its role in cancer progression
Interleukin-1α (IL-1α) is a major alarmin cytokine which triggers and boosts the inflammatory
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …
IL-1β induced methylation of the estrogen receptor ERα gene correlates with EMT and chemoresistance in breast cancer cells
AM Jiménez-Garduño, MG Mendoza-Rodríguez… - Biochemical and …, 2017 - Elsevier
Inflammation has been recently acknowledged as a key participant in the physiopathology of
oncogenesis and tumor progression. The inflammatory cytokine IL-1β has been reported to …
oncogenesis and tumor progression. The inflammatory cytokine IL-1β has been reported to …