IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating
immune cells in several cancer models. We hypothesized that IL-22 regulation would occur …

The idea of a potential link between cancer and inflammation was first proposed by R.
Virchow in the nineteenth century. However, clear evidence regarding a key role of …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …

Objective Long-standing chronic pancreatitis is an established risk factor for pancreatic
ductal adenocarcinoma (PDAC). Interleukin-1β (IL-1β) has been associated in PDAC with …

Traditional uses of herbal medicine have depended mostly on anecdotal evidence for much
of history. The increasing application of scientific rigor to the study some of these traditional …

Cytokines are pleiotropic polypeptides that control the development of and responses
mediated by immune cells. Cytokine classification predominantly relies on [1] the target …

Macroautophagy (hereafter autophagy) is a cellular “self-eating” process that is implicated in
many human cancers, where it can act to either promote or suppress tumorigenesis …

The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

Interleukin-1α (IL-1α) is a major alarmin cytokine which triggers and boosts the inflammatory
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …

Inflammation has been recently acknowledged as a key participant in the physiopathology of
oncogenesis and tumor progression. The inflammatory cytokine IL-1β has been reported to …