A natural products solution to diabetic nephropathy therapy

Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

[HTML][HTML] A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

Y Jiang, M Liu, H Liu, S Liu - Phytochemistry Reviews, 2020 - Springer
Abstract Stephania tetrandra S. Moore (S. tetrandra) is distributed widely in tropical and
subtropical regions of Asia and Africa. The root of this plant is known in Chinese as “Fen …

Sclareol ameliorates hyperglycemia‐induced renal injury through inhibiting the MAPK/NF‐κB signaling pathway

X Han, J Zhang, L Zhou, J Wei, Y Tu, Q Shi… - Phytotherapy …, 2022 - Wiley Online Library
Diabetic nephropathy (DN) represents the most serious complication of diabetes. Previous
studies have shown that the activation of nuclear factor kappa B (NF‐κB) and mitogen …

PP2 Ameliorates Renal Fibrosis by Regulating the NF‐κB/COX‐2 and PPARγ/UCP2 Pathway in Diabetic Mice

J Wei, X Deng, Y Li, R Li, Z Yang, X Li… - Oxidative Medicine …, 2021 - Wiley Online Library
Renal fibrosis is characterized by glomerulosclerosis and tubulointerstitial fibrosis in diabetic
nephropathy (DN). We aimed to evaluate the effects of PP2 on renal fibrosis of DN …

[HTML][HTML] Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors

Y Fan, Y Zhang, K Shi, S Cheng, D Pei, X Shu - Cell Death & Disease, 2022 - nature.com
Ferroptosis induced by detrimental accumulation of lipid peroxides has been recently linked
to a variety of pathological conditions ranging from acute tissue injuries to chronic …

[HTML][HTML] Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats

L Shan, L Tong, L Hang, H Fan - Biomedicine & Pharmacotherapy, 2019 - Elsevier
The present study evaluated the anti-inflammatory activity of fangchinoline in rheumatoid
arthritis-induced rats. Rats were grouped into sham (group I), rheumatoid arthritis (group II …

Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review

J Song, Y Liu, Y Guo, M Yuan, W Zhong, J Tang… - …, 2024 - Springer
Inflammation can be triggered by any factor. The primary pathological manifestations can be
summarized as the deterioration, exudation, and proliferation of local tissues, which can …

Propolis and its combination with boric acid protect against ischemia/reperfusion-induced acute kidney injury by inhibiting oxidative stress, inflammation, DNA damage …

F Geyikoglu, K Koc, S Colak, HS Erol, S Cerig… - Biological trace element …, 2019 - Springer
Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied
diseases directly linked to oxidative stress. In this regard, it is important to protect cells …

Identification of Fangchinoline as a novel autophagy inhibitor with an adjuvant of chemotherapy against lung cancer

Z Ren, Y Song, J Xian, Y Liao, Y Zhan, T Zhao… - Toxicology and Applied …, 2023 - Elsevier
Autophagy is a fundamental recycling pathway that enhances cellular resilience, promoting
survival. However, this survival mechanism can impede anti-cancer treatment strategies …

[HTML][HTML] Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease models

L Yi, M Luo, M Wang, Z Dong, Y Du - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Alzheimer's disease (AD) is a debilitating, progressive, neurodegenerative
disorder characterized by the deposition of amyloid-β (Aβ) peptides and subsequent …