NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

DH Ipsen, J Lykkesfeldt, P Tveden-Nyborg - Cellular and molecular life …, 2018 - Springer
Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

Mitochondria as a therapeutic target for common pathologies

MP Murphy, RC Hartley - Nature Reviews Drug Discovery, 2018 - nature.com
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death

S Tang, X Mao, Y Chen, L Yan, L Ye, S Li - Frontiers in immunology, 2022 - frontiersin.org
Liver transplantation is the ultimate method for treating end-stage liver disease. With the
increasing prevalence of obesity, the number of patients with non-alcoholic fatty liver, a …

Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease

R Ramanathan, AH Ali, JA Ibdah - International Journal of Molecular …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …

Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis

S Spahis, E Delvin, JM Borys, E Levy - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Nonalcoholic fatty liver disease (NAFLD), characterized by liver triacylglycerol
build-up, has been growing in the global world in concert with the raised prevalence of …

Nonalcoholic fatty liver disease (NAFLD). Mitochondria as players and targets of therapies?

A Di Ciaula, S Passarella, H Shanmugam… - International Journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Metabolic syndrome and associated diseases: from the bench to the clinic

DL Mendrick, AM Diehl, LS Topor… - Toxicological …, 2018 - academic.oup.com
Abstract Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, a
Society of Toxicology Contemporary Concepts in Toxicology (CCT) workshop was held on …

[HTML][HTML] Pathogenesis and prevention of hepatic steatosis

F Nassir, RS Rector, GM Hammoud… - Gastroenterology & …, 2015 - ncbi.nlm.nih.gov
Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …

Targeting oxidative stress for the treatment of liver fibrosis

T Luangmonkong, S Suriguga, HAM Mutsaers… - Reviews of Physiology …, 2018 - Springer
Oxidative stress is a reflection of the imbalance between the production of reactive oxygen
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS …