Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …

Non-coding RNAs (ncRNAs) are considered major players in physiological and pathological
processes based on their versatile regulatory roles in different diseases including …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Redox signaling refers to the specific and usually reversible oxidation/reduction modification
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …

Cardiac remodeling involves molecular, cellular, and in-terstitial changes that manifest
clinically as changes in size, shape, and function of the heart after injury or stress …

Aims Programmed necrosis (necroptosis) represents a newly identified mechanism of cell
death combining features of both apoptosis and necrosis. Like apoptosis, necroptosis is …

Heart failure (HF) is a leading cause of morbidity and mortality in the United States. Despite
a number of important therapeutic advances for the treatment of symptomatic HF, 1 the …

Early reperfusion of ischemic cardiac tissue remains the most effective intervention for
improving clinical outcome following myocardial infarction. However, abnormal increases in …