Programmed cardiac myocyte death via the intrinsic, or mitochondrial, pathway is a
mechanism of pathological ventricular remodeling after myocardial infarction and during …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle, a component of
the cellular reticular network that allows cells to adjust to a wide variety of conditions. The …

Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …

Despite progress in cardiovascular research and evidence-based therapies, heart failure is
a leading cause of morbidity and mortality in industrialized countries. Cardiac remodeling is …

Background—Autophagy is a molecular process that breaks down damaged cellular
organelles and yields amino acids for de novo protein synthesis or energy provision …

Purpose Necroptosis has been proposed as a mode of cell death that is a caspase-
independent programmed necrosis. We investigated whether necroptosis is involved in …

Mitochondrial dysfunctions critically affect cardiomyocyte survival during
ischemia/reperfusion (I/R) injury. In this scenario p53 activates multiple signaling pathways …

Aims: Oxidative stress and mitochondrial dysfunction participate together in the development
of heart failure (HF). mRNA levels of monoamine oxidase-A (MAO-A), a mitochondrial …

A heart under chronic stress undergoes cardiac remodelling, a process that comprises
structural and functional changes including cardiomyocyte hypertrophy, interstitial fibrosis …

Significance: Despite their serious side effects, anthracyclines (ANTs) are the most
prescribed chemotherapeutic drugs because of their strong efficacy in both solid and …