[HTML][HTML] Molecular mechanisms of cardiac pathology in diabetes–Experimental insights

U Varma, P Koutsifeli, VL Benson, KM Mellor… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Diabetic cardiomyopathy is a distinct pathology independent of co-morbidities such as
coronary artery disease and hypertension. Diminished glucose uptake due to impaired …

Glucagon‐like peptide‐1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPAR α pathway

L Wu, K Wang, W Wang, Z Wen, P Wang, L Liu… - Aging cell, 2018 - Wiley Online Library
Lipotoxicity cardiomyopathy is the result of excessive accumulation and oxidation of toxic
lipids in the heart. It is a major threat to patients with diabetes. Glucagon‐like peptide‐1 …

Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents

R Yang, C Tan, M Najafi - Inflammopharmacology, 2022 - Springer
The incidence of cardiovascular disorders is one of the most concerns among people who
underwent cancer therapy. The heart side effects of cancer therapy may occur during …

[HTML][HTML] Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice

Y Ma, X Zhang, H Bao, S Mi, W Cai, H Yan, Q Wang… - PloS one, 2012 - journals.plos.org
Recent evidence indicates that toll-like receptor (TLR) 2 and 4 are involved in the
pathogenesis of dilated cardiomyopathy (DCM), but the exact mechanisms of their actions …

Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca2+ Handling but Exacerbates Cardiac Dysfunction in CaMKIIδC Transgenic Mice

T Zhang, T Guo, S Mishra, ND Dalton… - Circulation …, 2010 - Am Heart Assoc
Rationale: We previously showed that transgenic mice expressing Ca2+/calmodulin-
dependent protein kinase II δC (CaMKII-TG) develop dilated cardiomyopathy associated …

Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond

J Zhang, D Liu, M Zhang… - British journal of …, 2019 - Wiley Online Library
Excessive death of cardiac myocytes leads to many cardiac diseases, including myocardial
infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades …

MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury

P Makhdoumi, A Roohbakhsh, G Karimi - Biomedicine & Pharmacotherapy, 2016 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene
regulators. They are involved in the pathogenesis of different disorders including heart …

Role of cAMP in cardiomyocyte viability: beneficial or detrimental?

Y Zhang, S Chen, L Luo, S Greenly, H Shi… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: 3′, 5′-cyclic AMP (cAMP) regulates numerous cardiac functions. Various
hormones and neurotransmitters elevate intracellular cAMP (i [cAMP]) in cardiomyocytes …

Role of cardiac magnetic resonance in the evaluation of dilated cardiomyopathy: diagnostic contribution and prognostic significance

M Francone - International Scholarly Research Notices, 2014 - Wiley Online Library
Dilated cardiomyopathy (DCM) represents the final common morphofunctional pathway of
various pathological conditions in which a combination of myocyte injury and necrosis …

The role of miR-214 in cardiovascular diseases

Y Zhao, M Ponnusamy, L Zhang, Y Zhang, C Liu… - European journal of …, 2017 - Elsevier
Cardiovascular disease (CVD) is the leading cause of death throughout the world. The
increase in new patients every year leads to a demand for the identification of valid and …