BNC Protects H9c2 Cardiomyoblasts from H2O2‐Induced Oxidative Injury through ERK1/2 Signaling Pathway

F Zhang, B Huang, Y Zhao, S Tang… - Evidence‐Based …, 2013 - Wiley Online Library
Buchang naoxintong capsule (BNC) is a traditional Chinese medicine approved for the
treatment of cerebrovascular and cardiovascular diseases. However, little is known about …

Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction

X Wang, TC Wan, A Lauth, AL Purdy, KR Kulik… - Journal of molecular and …, 2022 - Elsevier
Injury from myocardial infarction (MI) and consequent post-MI remodeling is accompanied
by massive loss of cardiomyocytes (CM), a cell type critical for contractile function that is for …

Cardiac telomere length in heart development, function, and disease

SA Booth, FJ Charchar - Physiological genomics, 2017 - journals.physiology.org
Telomeres are repetitive nucleoprotein structures at chromosome ends, and a decrease in
the number of these repeats, known as a reduction in telomere length (TL), triggers cellular …

Survivin gene therapy attenuates left ventricular systolic dysfunction in doxorubicin cardiomyopathy by reducing apoptosis and fibrosis

PJH Lee, D Rudenko, MA Kuliszewski… - Cardiovascular …, 2014 - academic.oup.com
Aims The aim of this study was to investigate anti-apoptotic gene therapy using ultrasound-
mediated plasmid delivery of survivin, an inhibitor of apoptosis protein, to prevent apoptosis …

[HTML][HTML] PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes

K Isodono, T Takahashi, H Imoto, N Nakanishi… - PloS one, 2010 - journals.plos.org
To identify novel transmembrane and secretory molecules expressed in cardiac myocytes,
signal sequence trap screening was performed in rat neonatal cardiac myocytes. One of the …

High‐dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy

AH Chaanine, RE Gordon… - Physiological …, 2015 - Wiley Online Library
Autophagy, macroautophagy and chaperone‐mediated autophagy (CMA), are upregulated
in pressure overload (PO) hypertrophy. In this study, we targeted this process at its induction …

Krüppel-like factor 15 reduces ischemia-induced apoptosis involving regulation of p38/MAPK signaling

B Wang, H Xu, J Kong, D Liu, W Qin, W Bai - Human Gene Therapy, 2021 - liebertpub.com
Cardiomyocyte apoptosis is a characteristic of a variety of cardiac diseases, including
myocardial infarction (MI). Krüppel-like factor 15 (KLF15) is a transcription factor of Krüppel …

[HTML][HTML] Momordica balsamina acetone leaf extract induces apoptosis and inhibits the invasiveness and migration of MCF-7 breast cancer cells

K Serala, KM Malemela, IT Boshielo, S Riedel… - South African Journal of …, 2024 - Elsevier
Despite its well-documented nutritional and medicinal properties, Momordica balsamina has
not received enough attention in cancer research. As a result, this study investigated …

Puma deletion delays cardiac dysfunction in murine heart failure models through attenuation of apoptosis

A Mandl, L Huong Pham, K Toth, G Zambetti… - Circulation, 2011 - Am Heart Assoc
Background—Puma (p53-upregulated modulator of apoptosis) is a proapoptotic Bcl-2 family
protein that serves as a general sensor in response to pathological apoptotic stimuli. In …

[PDF][PDF] Effects of apelin on proliferation and apoptosis in rat ovarian granulosa cells

L Shuang, W Jidong, P Hongjuan… - Clin Exp Obstet …, 2016 - researchgate.net
Objective: To investigate the influence of apelin on proliferation and apoptosis in rat ovarian
granulosa cells (GCs) in vitro. Materials and Methods: Primary culture of SD rat ovarian GCs …