Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …

Technical advances in genome sequencing and the implementation of next-generation
sequencing (NGS) in clinical oncology have paved the way for individualizing cancer patient …

Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

Background Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year
survival rate of less than 16%. Liquid biopsy (LB) assays based on detecting circulating …

While the genomes of normal tissues undergo dynamic changes over time, little is
understood about the temporal-spatial dynamics of genomes in premalignant tissues that …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

In the last fifty years, large efforts have been deployed in basic research, clinical oncology,
and clinical trials, yielding an enormous amount of information regarding the molecular …

In this article, we describe contrasting developmental aspects of paediatric and adult brain
tumours. We hypothesize that the formation of cancer progenitor cells, for both paediatric …

Although somatic mutations in colorectal cancer are well characterized, little is known about
the accumulation of cancer mutations in the normal colon before cancer. Here, we have …