A novel spinal neuron connection for heat sensation

H Wang, W Chen, Z Dong, G Xing, W Cui, L Yao… - Neuron, 2022 - cell.com
Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection

S Ahrens, S Jaramillo, K Yu, S Ghosh, GR Hwang… - Nature …, 2015 - nature.com
Selective processing of behaviorally relevant sensory inputs against irrelevant ones is a
fundamental cognitive function whose impairment has been implicated in major psychiatric …

Hippocampal interneurons in bipolar disorder

C Konradi, EI Zimmerman, CK Yang… - Archives of general …, 2011 - jamanetwork.com
Objective: To assess hippocampal volume, neuron number, and interneurons in the same
specimens of subjects with bipolar disorder and healthy control subjects. Design: Whole …

GeneAnalytics pathway analysis and genetic overlap among autism spectrum disorder, bipolar disorder and schizophrenia

NS Khanzada, MG Butler, AM Manzardo - International Journal of …, 2017 - mdpi.com
Bipolar disorder (BPD) and schizophrenia (SCH) show similar neuropsychiatric behavioral
disturbances, including impaired social interaction and communication, seen in autism …

Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia

C Chen, C Zhang, L Cheng, JL Reilly… - Bipolar …, 2014 - Wiley Online Library
Objectives Aberrant DNA methylation and gene expression have been reported in
postmortem brain tissues of psychotic patients, but until now there has been no systematic …

TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

BM Schwenk, H Hartmann, A Serdaroglu… - The EMBO …, 2016 - embopress.org
Nuclear clearance of TDP‐43 into cytoplasmic aggregates is a key driver of
neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar …

Modeling psychiatric disorders at the cellular and network levels

KJ Brennand, A Simone, N Tran, FH Gage - Molecular psychiatry, 2012 - nature.com
Although psychiatric disorders such as autism spectrum disorders, schizophrenia and
bipolar disorder affect a number of brain regions and produce a complex array of clinical …

Impairments in dendrite morphogenesis as etiology for neurodevelopmental disorders and implications for therapeutic treatments

T Copf - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Dendrite morphology is pivotal for neural circuitry functioning. While the causative
relationship between small-scale dendrite morphological abnormalities (shape, density of …

Long non-coding RNAs in neuronal aging

D Pereira Fernandes, M Bitar, FMJ Jacobs, G Barry - Non-coding RNA, 2018 - mdpi.com
The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been
associated with the emergence of sophisticated regulatory networks that may have …

The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin

W Choi, R Wolber, W Gerwat, T Mann… - Journal of cell …, 2010 - journals.biologists.com
Interactions between melanocytes and neighboring cells in the skin are important in
regulating skin color in humans. We recently demonstrated that the less pigmented and …