Neuregulin 3 signaling mediates nicotine-dependent synaptic plasticity in the orbitofrontal cortex and cognition
L Zhou, ML Fisher, RD Cole, TJ Gould… - …, 2018 - nature.com
Abstract Neuregulin 3 (NRG3) and ErbB4 have been linked to nicotine addiction; however,
the neuronal mechanisms and behavioral consequences of NRG3–ErbB4 sensitivity to …
the neuronal mechanisms and behavioral consequences of NRG3–ErbB4 sensitivity to …
Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain
CY Ding, YT Ding, H Ji, YY Wang, X Zhang, DM Yin - Cell & Bioscience, 2023 - Springer
Background Where the gene is expressed determines the function of the gene. Neuregulin 1
(Nrg1) encodes a tropic factor and is genetically linked with several neuropsychiatry …
(Nrg1) encodes a tropic factor and is genetically linked with several neuropsychiatry …
The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males
P Roussos, SG Giakoumaki, E Adamaki, P Bitsios - Biological psychiatry, 2011 - Elsevier
BACKGROUND:: Neuregulin-1 (NRG1) variations have been shown to modulate
schizophrenia candidate endophenotypes related to brain structure and function. The …
schizophrenia candidate endophenotypes related to brain structure and function. The …
The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity
J Wang, J Huang, S Yao, JH Wu, HB Li, F Gao… - Cell & Bioscience, 2021 - Springer
Background The ketogenic diet (KD) has been considered an effective treatment for
epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported …
epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported …
[HTML][HTML] Therapeutic role of neuregulin 1 type III in SOD1-linked amyotrophic lateral sclerosis
G Mòdol-Caballero, B García-Lareu, S Verdés, L Ariza… - …, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron (Mn) disease without
effective cure currently available. Death of MNs in ALS is preceded by failure of …
effective cure currently available. Death of MNs in ALS is preceded by failure of …
From “directed differentiation” to “neuronal induction”: Modeling neuropsychiatric disease: Supplementary issue: Stem cell biology
Aberrant behavior and function of neurons are believed to be the primary causes of most
neurological diseases and psychiatric disorders. Human postmortem samples have limited …
neurological diseases and psychiatric disorders. Human postmortem samples have limited …
[HTML][HTML] NRG1-ErbB4 signaling in the medial amygdala controls mating motivation in adult male mice
J Huang, YY Zhang, YY Qiu, S Yao, WT Qiu, JL Peng… - Cell Reports, 2024 - cell.com
Motivation-driven mating is a basic affair for the maintenance of species. However, the
underlying molecular mechanisms that control mating motivation are not fully understood …
underlying molecular mechanisms that control mating motivation are not fully understood …
The β2V287L nicotinic subunit linked to sleep-related epilepsy differently affects fast-spiking and regular spiking somatostatin-expressing neurons in murine prefrontal …
Mutant subunits of the neuronal nicotinic ACh receptor (nAChR) can cause Autosomal
Dominant Sleep-related Hypermotor Epilepsy (ADSHE), characterized by frontal seizures …
Dominant Sleep-related Hypermotor Epilepsy (ADSHE), characterized by frontal seizures …
Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice
TW Chohan, AA Boucher, JR Spencer… - Schizophrenia …, 2014 - academic.oup.com
Stress has been linked to the pathogenesis of schizophrenia. Genetic variation in neuregulin
1 (NRG1) increases the risk of developing schizophrenia and may help predict which high …
1 (NRG1) increases the risk of developing schizophrenia and may help predict which high …
Neuregulin 1 type I overexpression is associated with reduced NMDA receptor–mediated synaptic signaling in hippocampal interneurons expressing PV or CCK
D Kotzadimitriou, W Nissen, M Paizs, K Newton… - Eneuro, 2018 - eneuro.org
Hypofunction of N-methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic
interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder …
interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder …