Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has
a proven safety record when appropriately applied to eliminate weeds. However, over the …

Abnormal and exaggerated deposition of extracellular matrix is the hallmark of many fibrotic
diseases, including systemic sclerosis and pulmonary, liver, and kidney fibrosis. The …

Fibrosis is the formation or development of excess fibrous connective tissue (largely type I
collagen) in a tissue as a result of a reparative or reactive process. Fibrosis, or scarring, is a …

Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in
excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for …

The cystic fibrosis (CF) airway bacterial pathogen Pseudomonas aeruginosa secretes
multiple virulence factors. Among these, the redox active exotoxin pyocyanin (PCN) is …

Human amnion epithelial cells (hAECs) have attracted recent attention as a promising
source of cells for regenerative therapies, with reports that cells derived from human term …

Idiopathic Pulmonary Fibrosis (IPF) is characterized by injury and loss of lung epithelial
cells, accumulation of fibroblasts/myofibroblasts and abnormal remodeling of the lung …

Angiotensin II (ANGII) has been identified as a proapoptotic and profibrotic factor in
experimental lung fibrosis models, and patients with the ID/DD polymorphism of ANG …

Fibrosis or scarring of diverse organs and tissues is considered as a pathologic
consequence of a chronically altered wound healing response which is tightly linked to …