Garlic is generally used as a therapeutic reagent against various diseases, and numerous
studies have indicated that garlic and its derivatives can reduce the risk of various types of …

Purpose Bortezomib (BTZ) is used for the treatment of multiple myeloma (MM). However, a
significant proportion of patients may be refractory to the drug. This study aimed to …

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor (KSHV/vGPCR) is
a key molecule in the pathogenesis of Kaposi's sarcoma. We have previously shown that 1α …

Proteasome inhibitors, used in cancer treatment for their proapoptotic effects, have anti-
inflammatory and antifibrotic effects on animal models of various inflammatory and fibrotic …

Triple negative breast cancer (TNBC) cells express increased levels of the pro-inflammatory
and pro-angiogenic chemokine interleukin-8 (IL-8, CXCL8), which promotes their …

Since their introduction to the clinic 10 years ago, proteasome inhibitors have become the
cornerstone of anti-multiple myeloma therapy. Despite significant progress in understanding …

Gallstone disease is one of the most prevalent and costly gastrointestinal disorders
worldwide. Gallstones are formed in the biliary system by cholesterol secretions in bile …

Although dual EGFR/HER2 tyrosine kinase inhibitor lapatinib has provided effective clinical
benefits for HER2-positive breast cancer patients, acquired resistance to this drug remains a …

Various biological functions of Boron (B) compounds are known (Blevins & Lukaszewski,
1994; Tariq & Mott, 2007; Nielsen, 2008). Boron is found in nuts, vegetables, dried/fresh …

Efrapeptins (EF), a family of fungal peptides, inhibit proteasomal enzymatic activities and the
in vitro and in vivo growth of HT-29 cells. They are also known inhibitors of F 1 F 0-ATPase …