Melatonin and Its Role in the Epithelial-to-Mesenchymal Transition (EMT) in Cancer

C Martínez-Campa, V Álvarez-García… - Cancers, 2024 - mdpi.com
Simple Summary The epithelial-to-mesenchymal transition (EMT) is a process taking place
during carcinogenesis. The phenotypic changes include the acquisition of new properties …

Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma

W Zhu, C Fan, S Dong, X Li, H Chen… - Frontiers in …, 2023 - frontiersin.org
As a component of the innate immune system, there is emerging evidence to suggest that
neutrophils may play a critical role in the initiation and progression of hepatocellular …

[HTML][HTML] Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice

G Fang, S Wang, Q Chen, H Luo, X Lian, D Shi - Neoplasia, 2023 - Elsevier
The homeostasis of the gut microbiota and circadian rhythm is critical to host health, and
both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) …

Anterior gradient‐2 regulates cell communication by coordinating cytokine–chemokine signaling and immune infiltration in breast cancer

S Zhang, Q Liu, Y Wei, Y Xiong, Y Gu, Y Huang… - Cancer …, 2023 - Wiley Online Library
Abstract Anterior gradient‐2 (AGR2) is crucial to breast cancer progression. However, its
role in the tumor immune microenvironment remains unclear. RNA sequencing expression …

CRS: a circadian rhythm score model for predicting prognosis and treatment response in cancer patients

Y Liu, S Guo, Y Sun, C Zhang, J Gan, S Ning… - Journal of Translational …, 2023 - Springer
Background Circadian rhythm regulates complex physiological activities in organisms. A
strong link between circadian dysfunction and cancer has been identified. However, the …

Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinoma

W Hong, Y Zhang, S Wang, D Zheng, S Hsu, J Zhou… - Cancer Letters, 2024 - Elsevier
Aims DNA damage repair (DDR) plays a pivotal role in hepatocellular carcinoma (HCC),
driving oncogenesis, progression, and therapeutic response. However, the mechanisms of …

Leveraging a KRAS-based signature to predict the prognosis and drug sensitivity of colon cancer and identifying SPINK4 as a new biomarker

JT Huo, A Tuersun, SY Yu, YC Zhang, WQ Feng… - Scientific Reports, 2023 - nature.com
KRAS is one of the leading mutations reported in colon cancer. However, there are few
studies on the application of KRAS related signature in predicting prognosis and drug …

Aberrant R-loop–mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis

S Zhang, Y Liu, Y Sun, Q Liu, Y Gu, Y Huang, Z Zeng… - Molecular Cancer, 2024 - Springer
Dysregulation of R-loop homeostasis is closely related to various human diseases, including
cancer. However, the causality of aberrant R-loops in tumor progression remains unclear. In …

A signature based on circadian rhythm-associated genes for the evaluation of prognosis and the tumour microenvironment in HNSCC

C Wang, X Liu, P Nov, L Li, C Li, X Liao, L Li, K Du… - Scientific Reports, 2024 - nature.com
The morbidity and mortality rates of head and neck squamous cell carcinoma (HNSCC)
remain high worldwide. Therefore, there is an urgent need to identify a new prognostic …

Combined analysis of single-cell and bulk RNA sequencing reveals the expression patterns of circadian rhythm disruption in the immune microenvironment of …

H He, Y Yang, L Wang, Z Guo, L Ye… - Frontiers in …, 2023 - frontiersin.org
Background Circadian rhythm disruption (CRD) represents a critical contributor to the
pathogenesis of Alzheimer's disease (AD). Nonetheless, how CRD functions within the AD …