Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Background It has been widely accepted that monocytes are one of the central mediators
contributing to inflammaging. However, it remains unclear whether aged monocytes, similar …

Aging is associated with a low-grade, systemic inflammatory state defined as
“inflammaging”, ruled by the loss of proper regulation of the immune system leading to the …

Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Multiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a
disease of older adults (the median age at diagnosis is 70 years). The slow progression from …

Vaccination, being able to prevent millions of cases of infectious diseases around the world
every year, is the most effective medical intervention ever introduced. However …

Neutrophils are cells of the innate immune system that are extremely abundant in vivo and
respond quickly to infection, injury, and inflammation. Their constant circulation throughout …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Aims Brain disease, in its many forms, has recently demonstrated a great socio-economic
impact and represents one of the hardest challenges of present research. Although each …