Comorbid depression and anxiety spectrum disorders

JM Gorman - Depression and anxiety, 1996 - Wiley Online Library
The relationship between depression and anxiety disorders has long been a matter of
controversy. The overlap of symptoms associated with these disorders makes diagnosis …

[HTML][HTML] Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors

X Zhuang, C Gross, L Santarelli, V Compan… - …, 1999 - Elsevier
Dysfunctions of the serotonergic system have been implicated in a number of psychiatric
disorders including depression, anxiety and disorders of impulse control. To model these …

Blunted serotonergic responsivity in depressed inpatients

JJ Mann, PA McBride, KM Malone, M DeMeo… - …, 1995 - nature.com
We found a 38% lower maximal prolactin response to an oral challenge dose of 60 mg of dl-
fenfluramine relative to placebo in younger (< 30 years) depressed inpatients compared with …

The psychobiology of anxiolytic drugs: Part 1: Basic neurobiology

JJ Sandford, SV Argyropoulos, DJ Nutt - Pharmacology & therapeutics, 2000 - Elsevier
The authors provide an overview of the current state of knowledge with regards to the
neurobiological mechanisms involved in normal and pathological anxiety. A brief review of …

Investigation of cortisol levels in patients with anxiety disorders: a structured review

HY Elnazer, DS Baldwin - Behavioral neurobiology of stress-related …, 2014 - Springer
Anxiety disorders are common and distressing medical conditions, which typically arise in
adolescence or early adult life. They can persist for many years, reducing quality of life …

The pharmacology of anxiety

C Durant, D Christmas, D Nutt - Behavioral neurobiology of anxiety and its …, 2010 - Springer
Understanding the neurochemistry of anxiety is of fundamental importance in the
development and use of novel anxiolytics. Through measuring peripheral markers of brain …

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

FG Graeff, C Garcia-Leal, CM Del-Ben… - Anais da Academia …, 2005 - SciELO Brasil
A bibliographic search has been performed in MEDLINE using cortisol and panic as key-
words, occurring in the title and/or in the abstract. Human studies were selected, with no time …

Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats

J Pandaranandaka, S Poonyachoti… - Physiology & …, 2006 - Elsevier
Anxiety is a symptom reflecting the dysregulation of monoaminergic neurotransmitters which
may be modulated by estrogen. In our current study, we investigated the effects of chronic …

Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia

ME Tancer, RB Mailman, MB Stein, GA Mason… - Anxiety, 1994 - Wiley Online Library
We examined neuroendocrine correlates of central monoamine function in patients with the
generalized type of social phobia compared to healthy volunteers in order to test hypotheses …

Lactate: a prospective target for therapeutic intervention in psychiatric disease

Y Cai, H Guo, T Han, H Wang - Neural Regeneration Research, 2024 - journals.lww.com
Although antipsychotics that act via monoaminergic neurotransmitter modulation have
considerable therapeutic effect, they cannot completely relieve clinical symptoms in patients …