Simple Summary In recent years, several therapeutic advances have been made in clear
cell renal cell carcinoma (ccRCC) resulting in novel treatment regimens of increased …

Endothelial cells (ECs) that line vascular and lymphatic vessels are being increasingly
recognized as important to organ function in health and disease. ECs participate not only in …

Background Despite therapeutic advances, once a cancer has metastasized to the bone, it
represents a highly morbid and lethal disease. One third of patients with advanced clear cell …

Background Immunotherapy plus tyrosine kinase inhibitor (IO-TKI) has become the first-line
management for metastatic renal cell carcinoma (RCC), despite the absence of biomarkers …

Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer,
accounting for over 75% of cases. The asymptomatic nature of the disease contributes to …

Multiple-source single-cell datasets have accumulated quickly and need computational
methods to integrate and decompose into meaningful components. Here, we present inClust …

Background The outcomes of patients with clear cell renal cell carcinoma (ccRCC) were
dreadful due to lethal local recurrence and distant metastases. Accumulating evidence …

Kidney renal clear cell carcinoma (KIRC) is the most common histological type of renal
cancer, enhancer RNA plays a significant role in tumor growth, however, it has been less …

Abstract Background Tumor endothelial cells (TECs) represent the primary interface
between the tumor microenvironment and circulating immune cells, however their …

Cancer is one of the top 10 fatal diseases worldwide, among which advanced metastatic
carcinoma has the highest mortality rate. Sunitinib and immune checkpoint blockers are …