Fundamental to living cells is the capacity to differentiate into subtypes with specialized
attributes. Understanding the way cells acquire their fates is a major challenge in …

Microbes transiently differentiate into distinct, specialized cell types to generate functional
diversity and cope with changing environmental conditions. Though alternate programs …

Stochastic cell fate specification, in which a cell chooses between two or more fates with a
set probability, diversifies cell subtypes in development. Although this is a vital process …

Across the animal kingdom, visual systems have evolved to be uniquely suited to the
environments and behavioral patterns of different species. Visual acuity and color …

Color and polarization provide complementary information about the world and are detected
by specialized photoreceptors. However, the downstream neural circuits that process these …

The molecular processes that drive gene transcription are inherently noisy. This noise often
manifests in the form of transcriptional bursts, producing fluctuations in gene activity over …

Both microbes and multicellular organisms actively regulate their cell fate determination to
cope with changing environments or to ensure proper development. Here, we use synthetic …

Although cell fate specification is tightly controlled to yield highly reproducible results and
avoid extreme variation, developmental programs often incorporate stochastic mechanisms …

The central nervous system (CNS) exhibits an extraordinary diversity of neurons, with the
right cell types and proportions at the appropriate sites. Thus, to produce brains with specific …

During development, cells need to make decisions about their fate in order to ensure that the
correct numbers and types of cells are established at the correct time and place in the …