Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral
cavity. The substantial risk factors for OCSCC are the consumption of tobacco products …

Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma
(HNSCC). Identification of mutations that predict therapeutic response would be a major …

Almost thirty years ago, PI3K was discovered as a lipid kinase associated with certain
oncoproteins. The first decade of research on PI3K saw the identification, purification and …

Oral cancer is the most common form of head and neck squamous cell carcinoma (HNSCC)
and most frequently presents as oral squamous cell carcinoma (OSCC), which is associated …

The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …

Background Fifty percent of patients with muscle–invasive bladder cancer (MI-BC) die from
their disease and current chemotherapy treatment only marginally increases survival. Novel …

Multiple genetic and epigenetic events, including the aberrant expression and function of
molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle …

The incidence of oral squamous cell carcinoma (OSCC) is rising rapidly in developed
countries, posing a growing challenge due to the poor management of this type of …

Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and
genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations …