Background Fever is among the most common symptoms of people living in Africa, and
clinicians are challenged by the similar clinical features of a wide spectrum of potential …

Background Acute undifferentiated febrile illness (AUFI) is caused by a multitude of diverse
pathogens, with significant morbidity and mortality in the developing world. The objective of …

Rationale: Reducing the global burden of sepsis, a recognized global health challenge,
requires comprehensive data on the incidence and mortality on a global scale. Objectives …

Rapid urbanization in the global South is adding epidemiological and nutritional challenges
and increasing disease and health burdens for citizens. Greater movement of people …

Objectives To examine the impact of use of rapid diagnostic tests for malaria on prescribing
of antimicrobials, specifically antibiotics, for acute febrile illness in Africa and Asia. Design …

For 45 African countries/territories already reporting COVID-19 cases before 23 March 2020,
we estimate the dates of reporting 1,000 and 10,000 cases. Assuming early epidemic trends …

Febrile illness is a major burden in African children, and non-malarial causes of fever are
uncertain. In this retrospective exploratory study, we used metagenomic next-generation …

Acute febrile illness (AFI) is associated with substantial morbidity and mortality worldwide,
yet an etiologic agent is often not identified. Convalescent-phase serology is impractical …

Background The availability of reliable point-of-care tests for malaria has heralded a
paradigm shift in the management of febrile illnesses away from presumptive antimalarial …

Background Global assessments of antibiotic consumption have relied on pharmaceutical
sales data that do not measure individual-level use, and are often unreliable or unavailable …