Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Mef2 is a conserved and significant transcription factor in the control of muscle gene
expression. In cell culture Mef2 synergises with MyoD-family members in the activation of …

Despite tremendous success in understanding the chemical nature and the importance of
cation− π interactions in a range of biological processes, particularly in epigenetic …

Kabuki syndrome (KS) is a rare genetic disease that causes developmental delay and
congenital anomalies. Since the identification of MLL2 mutations as the primary cause of KS …

The MEF2 transcription factors have roles in muscle, cardiac, skeletal, vascular, neural,
blood and immune system cell development through their effects on cell differentiation …

In response to muscle injury, muscle stem cells integrate environmental cues in the
damaged tissue to mediate regeneration. These environmental cues are tightly regulated to …

Skeletal muscle stem cells (MuSCs) are required for regeneration of adult muscle following
injury, a response that demands activation of mainly quiescent MuSCs. Despite the need for …

Sarcopenia, a disorder characterized by age-related muscle loss and reduced muscle
strength, is associated with decreased individual independence and quality of life, as well as …

The orchestrated organization of epigenetic factors that control chromatin dynamism,
including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and chromatin …

During development, diverse cellular identities are established and maintained in the
embryo. Although remarkably robust in vivo, cellular identities can be manipulated using …