Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation
therapy (RT) and manifests acutely as radiation pneumonitis and chronically as radiation …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Objectives: Review the pathophysiology and common side effects of radiation therapy.
Outline strategies for the treatment of radiotherapy side effects. Describe the importance of …

Deregulation of normal regenerative responses to physical, chemical and biological toxins
in susceptible individuals leads to abnormal remodelling of extracellular matrix with …

Our understanding of how radiation kills normal and tumour cells has been based on an
intimate knowledge of the direct induction of DNA damage and its cellular consequences …

Acute radiation damage is most prominent in tissues with rapidly proliferating cells, such as
in epithelial surfaces of the skin or alimentary tract. Symptoms develop when functional cells …

With the recent success of checkpoint inhibitors and other immunomodulating agents, there
has been renewed interest in the combination of such agents with radiation. The biologic …

Bronchoalveolar lavage (BAL) is a commonly used procedure in the evaluation of lung
disease as it allows for sampling of the lower respiratory tract. In many circumstances, BAL …

The advent of novel immunotherapies in the treatment of cancers has dramatically changed
the landscape of the oncology field. Recent developments in checkpoint inhibition therapies …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …