There is extensive evidence that effective screening for major chromosomal abnormalities
can be provided in the first trimester of pregnancy. Prospective studies in a total of 200,868 …

Increased fetal nuchal translucency (NT) thickness between 11 and 14 weeks' gestation is a
common phenotypic expression of chromosomal abnormalities, including trisomy 21 …

The possibility of improving the effectiveness of antenatal screening for Down's syndrome by
measuring human chorionic gonadotrophin concentrations in maternal serum during the …

Background In 1968 the first antenatal diagnosis of Down's syndrome was made and
screening on the basis of selecting women of advanced maternal age for amniocentesis was …

To determine whether sonographic" markers" are associated with fetal Down syndrome
during the second trimester and to estimate the degree of risk of individual markers using …

ContextSecond-trimester prenatal ultrasound is widely used in an attempt to detect Down
syndrome in fetuses, but the accuracy of this method is unknown. ObjectiveTo determine the …

Hydrops revisited: Literature review of 1, 414 cases published in the 1980s Page 1 American
Journal of Medical Genetics 34366 -390 (1989) Hydrops Revisited: Literature Review of 1,414 …

Objective. To determine the risk of Down syndrome in fetuses with sonographic markers
using the Bayes theorem and likelihood ratios. Methods. We prospectively evaluated the …

A long-sought goal of medical genetics has been development of prenatal diagnostic
procedures that do not endanger the conceptus. Reliable and universal screening for …

Two hundred ten consecutive fetuses were identified as having renal pyelectasis among
7400 patients scanned during 1 year. Seven of these 210 fetuses had Down syndrome. We …