The tumor microenvironment (TME) is an essential intrinsic portion of hepatocellular
carcinoma (HCC) for the regulation of its origination, development, invasion, and metastasis …

Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

Tumor metastasis is a hallmark of cancer. The communication between cancer-derived
exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche …

The communication between tumor-derived elements and stroma in the metastatic niche has
a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control …

Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation‐related cancer and represents a paradigm …

Stress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the
stressors, which are counteracted by various physiological and behavioural adaptive …

KRAS is one of the most frequently mutated oncogenes in cancer, being a potent initiator of
tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to …

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the
human population. Different etiological factors such as hepatitis B and C virus, alcohol and …

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide.
Although it has been known that hepatic stellate cells (HSCs) play critical roles in the …

Accumulating evidence has indicated that oxidative stress (OS) is associated with the
development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely …