Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies

P Manna, SK Jain - Metabolic syndrome and related disorders, 2015 - liebertpub.com
Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …

The tumor microenvironment in esophageal cancer

EW Lin, TA Karakasheva, PD Hicks, AJ Bass… - Oncogene, 2016 - nature.com
Esophageal cancer is a deadly disease, ranking sixth among all cancers in mortality.
Despite incremental advances in diagnostics and therapeutics, esophageal cancer still …

Obesity and GERD

P Chang, F Friedenberg - Gastroenterology Clinics, 2014 - gastro.theclinics.com
The typical manifestations of gastroesophageal reflux disease (GERD) are heartburn and/or
regurgitation. GERD can be further classified into erosive GERD and nonerosive GERD …

Paracrine and endocrine effects of adipose tissue on cancer development and progression

J Park, DM Euhus, PE Scherer - Endocrine reviews, 2011 - academic.oup.com
The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …

[HTML][HTML] Roles of adipokines in digestive diseases: markers of inflammation, metabolic alteration and disease progression

ML Chang, Z Yang, SS Yang - International journal of molecular sciences, 2020 - mdpi.com
Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the
interorgan crosstalk network through adipokines, which cause pleiotropic effects, including …

[HTML][HTML] The pathophysiology of obesity and its clinical manifestations

RN Redinger - Gastroenterology & hepatology, 2007 - ncbi.nlm.nih.gov
Obesity is an exaggeration of normal adiposity and is a central player in the pathophysiology
of diabetes mellitus, insulin resistance, dyslipidemia, hypertension, and atherosclerosis …

Obesity, its associated disorders and the role of inflammatory adipokines in companion animals

AJ German, VH Ryan, AC German, IS Wood… - The Veterinary …, 2010 - Elsevier
Obesity is characterised by an expansion of white adipose tissue mass that can lead to
adverse health effects, such as decreased longevity, diabetes mellitus, orthopaedic and …

Mechanisms of obesity-induced gastrointestinal neoplasia

JO Alemán, LH Eusebi, L Ricciardiello, K Patidar… - Gastroenterology, 2014 - Elsevier
Obesity is among the fastest growing diseases worldwide; treatment is inadequate, and
associated disorders, including gastrointestinal cancers, have high morbidity and mortality …

Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin‐Induced PGE2, IL‐6, and IL‐8 Production

K Vuolteenaho, A Koskinen, M Kukkonen… - Mediators of …, 2009 - Wiley Online Library
Obesity is an important risk factor for osteoarthritis (OA) in weight‐bearing joints, but also in
hand joints, pointing to an obesity‐related metabolic factor that influences on the …

Central adiposity and risk of Barrett's esophagus

ZR Edelstein, DC Farrow, MP Bronner, SN Rosen… - Gastroenterology, 2007 - Elsevier
Background & Aims: Aside from chronic reflux, the etiology of Barrett's esophagus (BE)
remains largely unknown. This case-control study investigated body mass index (BMI) …