Role of obesity in the pathogenesis and progression of Barrett's esophagus

AK Chandar, PG Iyer - Gastroenterology Clinics, 2015 - gastro.theclinics.com
An exponential increase in the prevalence of obesity has been observed in the United
States in recent decades, 1 paralleled by a comparable increase in the incidence of …

Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction

NJ Clemons, WA Phillips, RV Lord - Cancer biology & therapy, 2013 - Taylor & Francis
Esophageal adenocarcinoma develops in response to severe gastroesophageal reflux
disease through the precursor lesion Barrett esophagus, in which the normal squamous …

Body mass index, smoking, and alcohol and risks of Barrett's esophagus and esophageal adenocarcinoma: a UK prospective cohort study

M Yates, E Cheong, R Luben, L Igali… - Digestive diseases and …, 2014 - Springer
Background The timing of the risk factors cigarette smoking, alcohol and obesity in the
development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) is …

[HTML][HTML] miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus

CM Smith, DI Watson, MP Leong… - World journal of …, 2011 - ncbi.nlm.nih.gov
AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal
epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase …

Promotion of melanoma growth by the metabolic hormone leptin

JA Ellerhorst, AH Diwan, SM Dang… - Oncology …, 2010 - spandidos-publications.com
We have previously shown that melanoma cells proliferate in response to the metabolic
hormones TRH and TSH. The objective of the present study was to test the hypothesis that a …

Eicosanoids and adipokines in breast cancer: from molecular mechanisms to clinical considerations

S Basu, R Nachat-Kappes… - Antioxidants & redox …, 2013 - liebertpub.com
Chronic inflammation is one of the foremost risk factors for different types of malignancies,
including breast cancer. Additional risk factors of this pathology in postmenopausal women …

Prognostic impact of body mass index in patients with squamous cell carcinoma of the esophagus

M Watanabe, T Ishimoto, Y Baba, Y Nagai… - Annals of surgical …, 2013 - Springer
Purpose To clarify the prognostic impact of body mass index (BMI) in patients with
esophageal squamous cell carcinoma (ESCC). Methods Two hundred forty-three patients …

Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and TGFα mediated transactivation of the epidermal growth factor …

OO Ogunwobi, ILP Beales - British journal of biomedical science, 2008 - Taylor & Francis
Obesity increases the risk of developing oesophageal adenocarcinoma (OAC) as well as
several other cancers. Leptin is secreted by adipocytes and serum leptin levels rise with …

Roles of gangliosides in hypothalamic control of energy balance: new insights

K Inamori, J Inokuchi - International Journal of Molecular Sciences, 2020 - mdpi.com
Gangliosides are essential components of cell membranes and are involved in a variety of
physiological processes, including cell growth, differentiation, and receptor-mediated signal …

Salivary cytokines in cell proliferation and cancer

M Schapher, O Wendler, M Gröschl - Clinica Chimica Acta, 2011 - Elsevier
While the presence of multiple systemic steroids, amines and peptides in saliva has been
reported, other hormones of the circulation do not appear in saliva. Substances present …