Protein dynamics describe the conformational changes in protein and play an essential role
in the function and evolution of proteins. Molecular dynamics (MD) can study protein …

Drug resistance is a global health threat costing society billions of dollars and impacting
millions of lives each year. Current drug design strategies are inadequate because they …

Abstract Globally, 62% of 38 million HIV-infected people are receiving antiretroviral therapy.
Inhibitors targeting the viral protease have been clinically successful as 9 protease inhibitors …

Design, Synthesis, and Biological Evaluation of Potent HIV-1 Protease Inhibitors With Novel
Bicyclic Oxazolidinone and Bis Squaramide Scaffolds Abstract In 2018, the World Health …

In Chapter 2, I describe an assay that enables the determination of sub-picomolar inhibition
constants for competitive inhibitors of HIV-1 protease. This advance was made possible by a …

Протеолиз является одним из генеральных механизмов биохимической регуляции в
жизнедеятельности практически всех организмов, а также участвует в инициации или …

The target molecule L is an exceptionally potent HIV-1 protease inhibitor that displays
several orders of magnitude improved antiviral activity over the FDA-approved drug …