A novel aberrant splice site mutation in RAB23 leads to an eight nucleotide deletion in the mRNA and is responsible for carpenter syndrome in a consanguineous …
Carpenter syndrome is caused by mutations in the RAB23 gene that encodes a small
GTPase of the Rab subfamily of proteins. Rab proteins are known to be involved in the …
GTPase of the Rab subfamily of proteins. Rab proteins are known to be involved in the …
Impact of C‐terminal truncations in the Arabidopsis Rab escort protein (REP) on REP–Rab interaction and plant fertility
M Gutkowska, M Kaus‐Drobek… - The Plant …, 2021 - Wiley Online Library
Lipid anchors are common post‐translational modifications for proteins engaged in
signaling and vesicular transport in eukaryotic cells. Rab proteins are geranylgeranylated at …
signaling and vesicular transport in eukaryotic cells. Rab proteins are geranylgeranylated at …
Rab geranylgeranylation occurs preferentially via the pre-formed REP–RGGT complex and is regulated by geranylgeranyl pyrophosphate
RA Baron, MC Seabra - Biochemical Journal, 2008 - portlandpress.com
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab
geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway …
geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway …
[HTML][HTML] Yarrowia lipolytica vesicle-mediated protein transport pathways
D Swennen, JM Beckerich - BMC Evolutionary Biology, 2007 - Springer
Background Protein secretion is a universal cellular process involving vesicles which bud
and fuse between organelles to bring proteins to their final destination. Vesicle budding is …
and fuse between organelles to bring proteins to their final destination. Vesicle budding is …
Heterologous Expression Studies of Saccharomyces cerevisiae Reveal Two Distinct Trypanosomatid CaaX Protease Activities and Identify Their Potential Targets
DZ Mokry, SP Manandhar, KA Chicola… - Eukaryotic …, 2009 - Am Soc Microbiol
The CaaX tetrapeptide motif typically directs three sequential posttranslational modifications,
namely, isoprenylation, proteolysis, and carboxyl methylation. In all eukaryotic systems …
namely, isoprenylation, proteolysis, and carboxyl methylation. In all eukaryotic systems …
[HTML][HTML] Rab proteins and the secretory pathway: the case of rab18 in neuroendocrine cells
R Vázquez-Martínez, MM Malagón - Frontiers in endocrinology, 2011 - frontiersin.org
The secretory pathway is a process characteristic of cells specialized in secretion such as
endocrine cells and neurons. It consists of different stages that are dependent on specific …
endocrine cells and neurons. It consists of different stages that are dependent on specific …
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT
Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal
prenylcysteine residues of CaaX proteins and some RAB GTPases. Deficiency of either …
prenylcysteine residues of CaaX proteins and some RAB GTPases. Deficiency of either …
Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines
M Ageberg, K Rydström, O Lindén, J Linderoth… - Experimental cell …, 2011 - Elsevier
Prenylation is a post-translational hydrophobic modification of proteins, important for their
membrane localization and biological function. The use of inhibitors of prenylation has …
membrane localization and biological function. The use of inhibitors of prenylation has …
Liver prenylated methylated protein methyl esterase is the same enzyme as sus scrofa carboxylesterase
OT Oboh, NS Lamango - Journal of biochemical and molecular …, 2008 - Wiley Online Library
Abstract The C‐terminal COOH of prenylated proteins is methylated to COOCH3. The
COOCH3 ester forms are hydrolyzed by prenylated methylated protein methyl esterase …
COOCH3 ester forms are hydrolyzed by prenylated methylated protein methyl esterase …
New insights in the regulation of Rab GTPases by G protein-coupled receptors
V Lachance, S Angers, JL Parent - Small GTPases, 2014 - Taylor & Francis
Cargo-mediated regulation of vesicular transport has received great attention lately. Rab
GTPases, forming the largest branch of the Ras GTPase superfamily, regulate almost every …
GTPases, forming the largest branch of the Ras GTPase superfamily, regulate almost every …