[HTML][HTML] Effect of P-glycoprotein (P-gp) inducers on exposure of P-gp substrates: review of clinical drug–drug interaction studies
M Elmeliegy, M Vourvahis, C Guo, DD Wang - Clinical pharmacokinetics, 2020 - Springer
Understanding transporter-mediated drug–drug interactions (DDIs) for investigational
agents is important during drug development to assess DDI liability, its clinical relevance …
agents is important during drug development to assess DDI liability, its clinical relevance …
Clinical implications of altered drug transporter abundance/function and PBPK modeling in specific populations: an ITC perspective
The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …
Data digitizing: accurate and precise data extraction for quantitative systems pharmacology and physiologically‐based pharmacokinetic modeling
JG Wojtyniak, H Britz, D Selzer… - CPT …, 2020 - Wiley Online Library
In quantitative systems pharmacology (QSP) and physiologically‐based pharmacokinetic
(PBPK) modeling, data digitizing is a valuable tool to extract numerical information from …
(PBPK) modeling, data digitizing is a valuable tool to extract numerical information from …
Risk of hospitalization with hemorrhage among older adults taking clarithromycin vs azithromycin and direct oral anticoagulants
Importance Clarithromycin is a commonly prescribed antibiotic associated with higher levels
of direct oral anticoagulants (DOACs) in the blood, with the potential to increase the risk of …
of direct oral anticoagulants (DOACs) in the blood, with the potential to increase the risk of …
Membrane transporters in drug development and as determinants of precision medicine
A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …
recognized. Since the initial publication from the International Transporter Consortium …
[HTML][HTML] Physiologically-based pharmacokinetic modeling to predict drug-drug interactions of dabigatran etexilate and rivaroxaban in the Chinese older adults
JEV Sia, X Lai, X Wu, F Zhang, H Li, C Cui… - European Journal of …, 2023 - Elsevier
Introduction Drug-drug interaction (DDI) is one of the major concerns for the clinical use of
NOACs in the older adults considering that coexistence of multiple diseases and comorbidity …
NOACs in the older adults considering that coexistence of multiple diseases and comorbidity …
Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug …
J Lang, L Vincent, M Chenel, K Ogungbenro… - European Journal of …, 2021 - Elsevier
Background Dabigatran etexilate (DABE) has been suggested as a clinical probe for
intestinal P-glycoprotein (P-gp)-mediated drug-drug interaction (DDI) studies and, as an …
intestinal P-glycoprotein (P-gp)-mediated drug-drug interaction (DDI) studies and, as an …
Pharmacokinetics and pharmacodynamics of direct oral anticoagulants
B Hindley, GYH Lip, AP McCloskey… - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Direct oral anticoagulants (DOACs) have overtaken vitamin K
antagonists to become the most widely used method of anticoagulation for most indications …
antagonists to become the most widely used method of anticoagulation for most indications …
Physiologically-Based Pharmacokinetic Modeling for Drugs Cleared by Non-Cytochrome P450 Enzymes: State-of-the-Art and Future Perspectives
AC Ozbey, S Fowler, K Leys, P Annaert… - Drug Metabolism and …, 2024 - ASPET
Physiologically-based pharmacokinetic (PBPK) modeling has become the established
method for predicting human pharmacokinetics (PK) and drug-drug interactions (DDI). The …
method for predicting human pharmacokinetics (PK) and drug-drug interactions (DDI). The …
Development and validation of LC–MS/MS method for simultaneous determination of dabigatran etexilate and its active metabolites in human plasma, and its …
Dabigatran is a direct thrombin inhibitor widely used for preventing various thrombotic
events. Although there are several established LC–MS/MS based methods for quantification …
events. Although there are several established LC–MS/MS based methods for quantification …