Construction and Characterization of a Live, Attenuated aroA Deletion Mutant of Pseudomonas aeruginosa as a Candidate Intranasal Vaccine

GP Priebe, MM Brinig, K Hatano, M Grout… - Infection and …, 2002 - Am Soc Microbiol
Antibodies to the lipopolysaccharide O antigen of Pseudomonas aeruginosa mediate high-
level immunity, but protective epitopes have proven to be poorly immunogenic, while …

Evidence for intracellular Pseudomonas aeruginosa

ZJ Resko, RF Suhi, AV Thota, AR Kroken - Journal of Bacteriology, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is a significant cause of global morbidity and mortality. Although it
is often regarded as an extracellular pathogen toward human cells, numerous investigations …

Pseudomonas aeruginosa stimulates phosphorylation of the airway epithelial membrane glycoprotein Muc1 and activates MAP kinase

EP Lillehoj, H Kim, EY Chun… - American Journal of …, 2004 - journals.physiology.org
We reported previously that Muc1 on the surface of epithelial cells was a receptor for
Pseudomonas aeruginosa (Lillehoj EP, Kim BT, and Kim KC. Am J Physiol Lung Cell Mol …

Intracellular Pseudomonas aeruginosa within the Airway Epithelium of Cystic Fibrosis Lung Tissues

K Malet, E Faure, D Adam, J Donner, L Liu… - American Journal of …, 2024 - atsjournals.org
Rationale: Pseudomonas aeruginosa (Pa) is the major bacterial pathogen colonizing the
airways of adult cystic fibrosis (CF) patients and causes chronic infections that persist …

Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa

FJ Byfield, M Kowalski, K Cruz… - The Journal of …, 2011 - journals.aai.org
In addition to its antibacterial activity, the cathelicidin-derived LL-37 peptide induces multiple
immunomodulatory effects on host cells. Atomic force microscopy, F-actin staining with …

Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src

XM Chen, BQ Huang, PL Splinter, H Cao, G Zhu… - Gastroenterology, 2003 - Elsevier
BACKGROUND & AIMS:: Cryptosporidium parvum invasion of epithelia requires
polymerization of host cell actin at the attachment site. We analyzed the role of host cell c …

[HTML][HTML] The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa

A Brandel, S Aigal, S Lagies, M Schlimpert… - Cellular and Molecular …, 2021 - Springer
The opportunistic pathogen Pseudomonas aeruginosa has gained precedence over the
years due to its ability to develop resistance to existing antibiotics, thereby necessitating …

Hyperacidification in cystic fibrosis: links with lung disease and new prospects for treatment

J Poschet, E Perkett, V Deretic - Trends in molecular medicine, 2002 - cell.com
A new link between the genetic defect and lung pathology in cystic fibrosis (CF) has been
established by the recent discovery of an abnormally acidic pH in the organelles of CF …

A Model of Intracellular Persistence of Pseudomonas aeruginosa in Airway Epithelial Cells

JK Malet, LC Hennemann, EML Hua… - Cellular …, 2022 - Wiley Online Library
Pseudomonas aeruginosa (Pa) is a major human pathogen capable of causing chronic
infections in hosts with weakened barrier functions and host defenses, most notably airway …

Role of Apoptosis in Pseudomonas aeruginosa Pneumonia

RS Hotchkiss, WM Dunne, PE Swanson, CG Davis… - Science, 2001 - science.org
Apoptosis plays a central role in the complex balance between invading pathogen and host
defense. Depending on the pathogen, apoptosis of host cells may be beneficial or …