[HTML][HTML] Viral vector-based gene therapy

X Li, Y Le, Z Zhang, X Nian, B Liu, X Yang - International Journal of …, 2023 - mdpi.com
Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

[HTML][HTML] Appraisal for the potential of viral and nonviral vectors in gene therapy: A review

MH Butt, M Zaman, A Ahmad, R Khan, TH Mallhi… - Genes, 2022 - mdpi.com
Over the past few decades, gene therapy has gained immense importance in medical
research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer's …

[HTML][HTML] Cell-penetrating peptide-based delivery of macromolecular drugs: development, strategies, and progress

Z Sun, J Huang, Z Fishelson, C Wang, S Zhang - Biomedicines, 2023 - mdpi.com
Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …

Expression of codon-optimized PDCoV-RBD protein in baculovirus expression system and immunogenicity evaluation in mice

N Wang, Z Wang, M Ma, X Jia, H Liu, M Qian… - International Journal of …, 2023 - Elsevier
Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that
mainly infects piglets, and causes huge losses to the pig industry. However, there are still no …

[HTML][HTML] Solutions against emerging infectious and noninfectious human diseases through the application of baculovirus technologies

AM Targovnik, JA Simonin, GJ Mc Callum… - Applied microbiology …, 2021 - Springer
Baculoviruses are insect pathogens widely used as biotechnological tools in different fields
of life sciences and technologies. The particular biology of these entities (biosafety viruses 1; …

Engineering strategies for insect viruses and microbes for dsRNA production and delivery to insects for targeted gene silencing

Q Xue, É Avila dos Santos, G Smagghe… - Entomologia …, 2023 - biblio.ugent.be
RNA interference (RNAi)-based pest control is viewed as a safe and effective method for
insect pest control. However, the stability and efficient cellular delivery of the double …

Genetically modified cell sheets in regenerative medicine and tissue engineering

Z Jiang, N Li, D Zhu, L Ren, Q Shao, K Yu, G Yang - Biomaterials, 2021 - Elsevier
Genetically modified cell sheet technology is emerging as a promising biomedical tool to
deliver therapeutic genes for regenerative medicine and tissue engineering. Virus-based …

[HTML][HTML] Investigation and restoration of BEST1 activity in patient-derived RPEs with dominant mutations

C Ji, Y Li, A Kittredge, A Hopiavuori, N Ward, P Yao… - Scientific reports, 2019 - nature.com
Abstract BEST1 is a Ca2+-activated Cl− channel predominantly expressed in retinal pigment
epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified …

Baculovirus as versatile vectors for protein display and biotechnological applications

CH Tsai, SC Wei, HR Lo, YC Chao - Current issues in molecular biology, 2019 - mdpi.com
The baculovirus-insect cell system has long been deployed for a variety of applications
including for use as biopesticides, for recombinant protein production, transient transgene …

[HTML][HTML] Methods of miRNA delivery and possibilities of their application in neuro-oncology

I Gareev, O Beylerli, T Rasim, T Ilyasova… - Non-coding RNA …, 2023 - Elsevier
In the current phase of medical progress, practical neuro-oncology faces critical challenges.
These include the quest for and development of innovative methodological approaches, as …