Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

Abstract The HNK-1 (Leu-7) monoclonal antibody was used to enumerate and characterize
the level of blood granular lymphocytes in 247 cancer patients. The results were compared …

In this article the evidence pertaining to the perspectives for clinical applicability of
interferons as antitumor drugs is critically reviewed. The mechanisms by which interferons …

The natural killer (NK) activity of peripheral blood mononuclear cells from 25 patients with
squamous cell carcinoma of the lung, malignant melanoma, or epitheloid cancers of the …

Four patients out of twenty with renal cancer and melanoma undergoing cancer
immunotherapy with interleukin 2 (IL-2) and interferon alpha-2 (IFN-α 2) had laboratory …

Partially purified human beta interferon (HuIFN-β) was administered to six patients with
metastatic breast carcinoma by the intramuscular route at doses of 3× 106 and 6× 106 units …

Eleven patients with metastasized breast cancer received 8 intramuscular injections of 6× 10
6 units of human fibroblast interferon over a period of 40 days. The injections did not cause …

Decreased peripheral blood natural killer (NK) cell lytic activity may be associated with
tumor presence. We evaluated peripheral blood NK lytic activity in 38 patients with …

Patients with metastatic cancer were given single intramuscular injections of 10 7 units of
partially purified preparations of either leukocyte or fibroblast IFN. Serum levels of interferon …

This study investigated the effect of various clinically used chemotherapeutic agents on non-
modulated and human alpha Interferon (IFN) modulated natural killer cell (NK) activity. The …